Quality Control Of Tablets Flashcards

1
Q

What are the quality control test of tablets

A
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2
Q

Explain the color as the organoleptic property of the tablet

A
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3
Q

Explain the odor as the organoleptic property of the tablet

A
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4
Q

Explain the taste as the organoleptic property of the tablet

A
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5
Q

List the official quality control test

A

Weight variation test
Disintegration test
Dissolution test
Drug content

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6
Q

Why should the weight of tablets routinely measured ?

A

To help ensure that the tablet contains the proper amount of drug

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7
Q

Explain the in practice weight variation test

A
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8
Q

What is the limit provided by the USP for the weight variation

A
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9
Q

Explain the disintegration test

A
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10
Q

What is the disintegration test essential for ?

A
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11
Q

What is the disintegration time for uncontested USP tablets the lowest and maximum

A

5 minutes
30 minutes maximum

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12
Q

What is the disintegration for enteric coated tablets

A
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13
Q

What is the limit for disintegration test

A
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14
Q

What does the dissolution test (in vitro drug release) measure

A
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15
Q

What equipment is used for the dissolution / in vitro drug release test

A
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16
Q

Describe the method of dissolution test

A
17
Q

The potency of tablet is expressed in terms of what

A
18
Q

What is the potency range of digitoxin

A
19
Q

What is the potency for large - dose drugs

A
20
Q

What do the potency analytical methods require

A
21
Q

When can weight be used as a potency indicator

A
22
Q

What are the three factors that can directly contribute to content uniformity problems in tablets

A
23
Q

What are the non official quality control test for tablets

A

Hardness
Friability test
Tablet thickness

24
Q

Define tablet hardness

A
25
Q

What is done to perform the hardness test

A
26
Q

What is the device used for hardness test

A

Erweka hardness tester

27
Q

What is the importance of the hardness test

A
28
Q

What is the disadvantage of tablets that tent to powder

A
29
Q

Explain the friability test

A
30
Q

What is the acceptable loss weight of the tablet for the friability test

A

0.8 %

31
Q

What is the only dimensional variable related to the compression process

A

Thickness of the tablet

32
Q

The thickness of individual tablets may be measured with what

A

Micrometer

33
Q

What is the limit for tablet thickness

A
34
Q

Why should thickness be controlled

A
35
Q

What are the characteristics of ideal tablets

A