Oral Controlled Systems Flashcards

1
Q

List the oral controlled systems

A
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2
Q

What is the matrix system

A
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3
Q

In the matrix system the drug is dispersed in what

A
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4
Q

In matrix system the drug release rate is controlled by what

A

By the type and proportion of polymer used in the preparations

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5
Q

What are the types of matrix system

A

Hydrophobic matrices
Lipid matrices
Hydrophilic matrices ( swellable controlled release systems )

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6
Q

Explain the hydrophobic matrices
Mentioned what is the sustained release produced due to and the rate controlling step

A
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7
Q

The mechanism of drug release don hydrophobic matrices is what

A

Diffusion

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8
Q

Explain lipid matrices

A
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9
Q

Where are Hydrophilic matrices (swellable controlled release systems ) used in

A
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10
Q

Explain Hydrophilic matrices

A
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11
Q

Explain the mechanism of the swellable controlled release system

A
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12
Q

Explain the reservoir system

A
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13
Q

What is the drug release rate controlled by in the reservoir systems

A
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14
Q

What is the mechanism of action of reservoir system

A
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15
Q

In reservoir system the release pattern Is what

A

Diffusion controlled

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16
Q

Explain the membranes in the reservoir systems

A
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17
Q

What is an advantage of reservoir system

A
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18
Q

Explain osmotic system

A
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19
Q

What are the components of osmotic systems

A

Core (drug + osmotic agent)
Semi permeable membrane
Delivery orifice

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20
Q

Explain the core component of osmotic system

A
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21
Q

Explain the semi permeable membrane component of the osmotic system

A
22
Q

Explain the delivery orifice component of the osmotic system

A
23
Q

What is the difference between diffusion based systems and osmotic system

A
24
Q

What are the types of osmotic systems

A

Single compartment osmotic system
Multi compartment osmotic system

25
Q

Explain the Single compartment osmotic system

A
26
Q

Explain the multi compartment osmotic system

A
27
Q

What does the mechanism of action of osmotic system include

A

Water influx
Osmotic pressure generation
Controlled drug release

28
Q

Explain the water influx mechanism of osmotic system

A
29
Q

Explain the osmotic pressure generation mechanism of osmotic system

A
30
Q

Explain the controlled drug release mechanism of osmotic system

A
31
Q

Explain ion exchange complexes and their characteristics

A
32
Q

What are the components of the ion exchange system

A

Ion exchange resin
Drug ion complex (rasinate)
GI fluids (ion source)

33
Q

Explain the ion exchange resin component of the ion exchange complexes

A
34
Q

Explain the drug ion complex (rasinate) component of the Dion exchange simplexes

A
35
Q

Explain the GI fluids component of the ion exchange complexes

A
36
Q

What does the mechanism of action of ion exchange complexes include

A

Binding of drug to resin
Ion exchange process in the GI tract
Controlled drug release

37
Q

Explain the binding of drug to resin mechanism of ion exchange complexes

A
38
Q

Explain the ion exchange process in GI fluid tract mechanism of ion exchange complexes

A
39
Q

Explain the controlled drug release mechanism of ion exchange complexes

A
40
Q

Explain the floating system

A
41
Q

What is the goal of the floating system

A
42
Q

What are the components of the floating system

A

Low density materials: hydrocolloid gel formation, gas generating agents

43
Q

Explain the low density materials components of the floating system

A
44
Q

Explain the hydrocolloid gel formation components of the floating system

A
45
Q

Explain the gas generating agents components of the floating system

A
46
Q

Explain the mechanism of action of the floating system

A
47
Q

Explain the multi particular systems

A
48
Q

What are the components of multi particulate systems

A

Multiple drug units (pellets, beads, granules, microspheres )
Coating or encapsulation

49
Q

Explain the multiple drug units component of the multi particulate system

A
50
Q

Explain the coating or encapsulation component of the multi particulate systems

A
51
Q

Explain the mechanism of action of multi particulate systems

A