Sulfonamides Flashcards
1
Q
What is the mechanism of action of sulfonamides?
A
inhibit sequential steps in folate synthesis = BACTERIOSTATIC
2
Q
What is the common sulfonamide used in the hospital?
A
Bactrim/Septra = TMP/SMX = Trimethoprim Sulfamethoxazole
3
Q
What coverage do sulfonamides have and what are 6 organisms that they cover for specifically? (PNTLIS)
A
Coverage: Gram + and most Gram - but not Pseudomonas
Unusual Coverage: Pneumocystis jiroveci, Nocardia, Toxoplasmosis, Listeria, Isospora, Stenotrophomonas
4
Q
What are sulfonamides typically used as treatment for?
A
skin/soft tissue infections due to MRSA coverage
5
Q
What are 6 possible side-effects of sulfonamide use?
A
- hypersensitivity
- rash
- dose-dependent bone marrow suppression
- elevated creatinine
- hyperkalemia
- GI side effects
6
Q
What would be seen if a patient with G6PD Deficiency took sulfonamides?
A
Hemolysis and methemoglobinemia
