Rifamycins

Question 1

What 4 medications are included in the Rifamycins family?

Answer 1

1. Rifampin
2. Rifaximin
3. Rifapentine
4. Rifabutin

Question 2

What forms are Rifampin and Rifaximin available in?

Answer 2

Rifampin - PO or IV

Rifaximin - PO

Question 3

What 3 things is Rifaximin used to treat?

Answer 3

1. Traveler’s Diarrhea
2. Hepatic Encephalopathy
3. C. difficile

nonabsorbable analog of Rifampin

Question 4

What spectrum of coverage does Rifampin have? (4)

Answer 4

1. Gram (+)
2. Gram (-)
3. Mycobacterium
4. Intracellular

Question 5

What 4 infections is Rifampin commonly used to treat for?

Answer 5

1. Active TB (with other meds)
2. Latent TB (2nd-line)
3. N. meningitidis contact PPx
4. Staphylococcus prosthetic infections

Question 6

What is Rifampin used to treat Staphylococcus prosthetic infections?

Answer 6

penetrates bacterial biofilms

Question 7

What are 4 possible side-effects of Rifampin use?

Answer 7

1. ORANGE body fluid discoloration
2. hepatotoxicity
3. rash
4. rare bone marrow suppression

Question 8

What is Rifampin’s effect on CYP enzyme?

Answer 8

potent INDUCER of CYP