Antibiotics with Anaerobe Coverage

Question 1

What 5 families of antibiotics are typically used to cover for infections with Anaerobes?

Answer 1

1. Metronidazole
2. Clindamycin
3. PCN/Beta-lactamase inhibitos
4. Carbapenems
5. 2nd Generation Cephalosporins

Question 2

What is the brand name of Metronidazole?

Answer 2

Flagyl

Question 3

What is the MOA of Metronidazole?

What two groups of infections is it commonly used to treat?

Answer 3

selectively taken up by anaerobic bacteria and reduced by proteins in the electron transport chain, leading to DNA disruption

• treats Anaerobes AND protozoans

Question 4

What 3 organisms does Metronidazole not have good coverage against?

Answer 4

Propionibacterium
Actinomyces
Lactobacillus

Question 5

Which antibiotic is used for anaerobe infections above vs below the diaphragm: Metronidazole vs Clindamycin?

Which of these two meds has CNS penetration?

Answer 5

ABOVE diaphragm = Clindamycin
BELOW diaphragm = Metronidazole

Metronidazole HAS CNS penetration

Question 6

What effect can Metronidazole cause if taken with alcohol?

Answer 6

Disulfiram-like reaction