Polyenes (Antifungal) Flashcards
1
Q
What is the MOA of polyenes?
A
binds ergosterol in membrane and forms membrane pores = fungicidal
2
Q
What are 3 common polyene medications?
A
Amphoterecin B, Abelcet, Ambisome
3
Q
What are the antifungals of choice for severe Zygomycetes, Cryptococcal Meningitis, and severe endemic fungal infections?
A
Polyenes
4
Q
What are 4 common side-effects of Polyene use?
A
- Nephrotoxicity
- Seizures
- Hypotension
- Bradycardia