Sulfonamides Flashcards
Sulfonamides
Sulfamethoxazole
Sulfisoxazole
Sulfacetamide
Sulfadiazine
MOA sulfonamides
inhibitors of dihydropteroate synthase which mammals lack
Are sulfonamides bactericidal or static
Bacteriostatic
What are sulfamethoxazole and sulfisoxazole used for
uncomplicated UTIs caused by susceptible organisms
What is sulfamethoxazole commonly used in combo with
trimethoprim
What is sulfadiazine used for
silver sulfadiazine for topical treatment of burn infections and skin infections
Sulfacetamide use
ophthalmic ointment and drops for blepharitis, conjunctivitis, and trachoma
Main ADE sulfonamides
Skin rash –> Stevens_johnson syndrome
Crystalluria
Hemolytic anemia in patients with G6PD deficiency
Jaundice –> kernicterus in neonates
Contraindications of sulfonamides
Newborn infants due to danger of kernicterus
Do not use in late stages of pregnancy