Sulfonamides Flashcards

1
Q

Sulfonamides

A

Sulfamethoxazole
Sulfisoxazole
Sulfacetamide
Sulfadiazine

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2
Q

MOA sulfonamides

A

inhibitors of dihydropteroate synthase which mammals lack

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3
Q

Are sulfonamides bactericidal or static

A

Bacteriostatic

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4
Q

What are sulfamethoxazole and sulfisoxazole used for

A

uncomplicated UTIs caused by susceptible organisms

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5
Q

What is sulfamethoxazole commonly used in combo with

A

trimethoprim

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6
Q

What is sulfadiazine used for

A

silver sulfadiazine for topical treatment of burn infections and skin infections

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7
Q

Sulfacetamide use

A

ophthalmic ointment and drops for blepharitis, conjunctivitis, and trachoma

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8
Q

Main ADE sulfonamides

A

Skin rash –> Stevens_johnson syndrome
Crystalluria
Hemolytic anemia in patients with G6PD deficiency
Jaundice –> kernicterus in neonates

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9
Q

Contraindications of sulfonamides

A

Newborn infants due to danger of kernicterus
Do not use in late stages of pregnancy

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