Carbapenems Flashcards
1
Q
Carbapenems
A
Imipenem
Meropenem
Ertapenem
Doripenem
2
Q
Structure of carbapenems
A
penicillin-like structure in which sulfur atom of thaizolidine ring is replaced by carbon atom
3
Q
What were carbapenems once called?
A
Gorillacillins
4
Q
What is imipenem inactivated by?
A
Renal dehydropeptidase
5
Q
What is Imipinem used in combo with
A
cilastatin (dehydropeptidase inhibitor)
6
Q
Main ADE of carbapenems
A
seizures in patients with epilepsy, anemia, leukopenia, and other blood dyscrasias
7
Q
DOC Carbapenems
A
ESBL-producing GNRs
8
Q
Are Carbapenems bactericidal or static?
A
Bactericidal
9
Q
What types of bacteria are carbapenems used for?
A
a wide range of gram positive and gram negative bacteria