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PHARM 2 > Cephalosporins > Flashcards

Cephalosporins Flashcards

1
Q

Each successive generation of Cephalosporins has —-

A

broader gram negative coverage with the exception of 5th generation (approved for MRSA)

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2
Q

MOA Cephalosporins

A

inhibit cell wall synthesis by blocking cross linking —> bind to PBP

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3
Q

Are cephalosporins bactericidal or static?

A

Bactericidal

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4
Q

First generation coverage

A

Gram positive + PEcK

Proteus
E. coli
Klebsiella

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5
Q

What first generation cephalosporin is given for surgical prophylaxis?

A

Cefazolin

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6
Q

Second generation coverage

A

gram positive + HENPEcK

Hemophilus
Enterobacteri
Neisseria
Proteus
E coli
Klebsiella

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7
Q

What are second generation cephs used for?

A

Respiratory tract infections caused by hemophilus

OM caused by hemophilus resistant to amoxicillin

Intra-abdominal, gynecologic, and biliary tract infections

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8
Q

What medications are used for OM caused by hemophilus resistant to amoxicillin?

A

PO Cefprozil and Cefuroxime axetil

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9
Q

What second generation cephalosporin is given for intra-abdominal, gynecologic, and biliary tract infections?

A

Cefotetan (IM, IV)

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10
Q

What differentiates 2nd generation cephalosporins - enteric from other cephalosporins

A

activity against Bacteroides fragilis

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11
Q

What third generation cephalosporin is active against some strains of pseudomonas?

A

Ceftazidime

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12
Q

Ceftriaxone

A

used as single dose for gonorrhea
biliary excretion (don’t have to worry about renal dosing)
long half life
third generation cephalosporin

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13
Q

Clinical indications for 3rd generation cephalosporins

A

OM
Pneumonia
meningitis
UTI
advanced Lyme disease

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14
Q

What is the only 4th generation Cephalosporin?

A

Cefepime (IV)

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15
Q

What does Cefepime have reliable coverage against?

A

Pseudomonas

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16
Q

Risk of Cefepime

A

encephalopathy

17
Q

5th generation Cephalosporin

A

Ceftaroline (MRSA)

18
Q

DOC 3rd generation Cephs

A

gonorrhea and meningitis (Ceftriaxone)

19
Q

what is Ceftriaxone DOC for?

A

Meningitis & gonorrhea

20
Q

Which cephalosporin has good CNS penetration for meningitis?

A

Ceftriaxone

21
Q

What is the only cephalosporin available PO or parenteral?

A

Cefuroxime (2nd gen)

22
Q

Which cephs can cause platelet dysfunction and bleeding and disulfiram-like rxn?

A

Cefemandole
Cefmetazole
Cefoperazone (3rd)
Cefotetan

PHARM 2 (22 decks)

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