Studies Flashcards
CAROLINA
Glimepiride and `
- Relative benefits known
Look AHEAD
Weight Loss effect on CV endpoints
- No effect, stopped due to futility
EDIC
Effects of Intense Insulin
- Reduces microvascular and macrovascular complications
- Increases risk of hypoglycemia
DCCT
Effects of Intense Insulin
- Reduces microvascular and macrovascular complications
- Increases risk of hypoglycemia
FDPS
Finish Diabetes Prevention Study
- Lifestyle Intervention reduces progression of type 2 diabetes
ORIGIN
Insulin effect on CV mortality
- No effect
UKPDS
Study showing that metformin had solid CV benefits
- Was proven to be flawed due to small sample sizes
Does not reduce progression of diabetes or have CV benefit
- Only glycemic control
DREAM
Diabetes Reduction Assessment Medication
- Rosiglitazone: Good Risk Reduction
- Ramipril: No Significant Difference
ACT Now
Pioglitazone
- Effective Risk Reduction
Da Qing
Lifestyle Intervention reduces progression of type 2 diabetes
Stop NIDDM
Acarbose
- Slight Risk Reduction
DPP
Diabetes Prevention Program
- Lifestyle Intervention reduces progression of type 2 diabetes
- Metformin
–> Slight Risk Reduction
SPREAD-DIMCAD
Metformin vs Glipizide
- Showed that metformin was better
