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PHARM 343 > Endocrine and Cardiovascular Lab > Flashcards

Endocrine and Cardiovascular Lab Flashcards

1
Q

What is released from Heart when its damaged

A

Protein and Enzyme

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2
Q

Hypopituitarism
- Kind of condition
- Lab Values

A

Adrenal Insufficiency
- Pituitary gland dont release CRH

Low ACTH
Low Cortisol

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3
Q

Adrenal Lab Values and Time of Day

A

Reference values depend on the time of day

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4
Q

Cushing’s Disease (Pituitary Adenoma)
- Kind of condition
- Lab Values

A

High ACTH
High Cortisol

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5
Q

3 Types of Lipids

A

Cholesterol (Major building resource - Cell membranes, hormones)
- Marker of heart disease

Triglycerides (Energy Source)
- Muscles

Phospholipids (make up all cell membrane)

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6
Q

Hyperthyroidism (8)
- Symptoms

A
  • Weight Loss
  • Heat Intolerance
  • Palpitations
  • Tremors
  • Nervousness
  • Sweating
  • Muscle Weakness
  • Goiter
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7
Q

Hypothyroidism (6)
- Symptoms

A
  • Weight Gain
  • Dry Skin
  • Cold Intolerance
  • Constipation
  • Menstrual Irregularities
  • Fatigue
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8
Q

Cushing’s Disease
(Adrenal Adenoma)

A

Low ACTH
High Cortisol

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9
Q

Clotting Cascade Pathways

A

Intrinsic and Extrinsic paths
- Leads to two different kinds of lab values

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10
Q

Oral Glucose Tolerance Test

A

Sample taken 2 hours after 75 gm glucose load

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11
Q

Hypothyroidism Lab Values

A

High TSH
Low T4

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12
Q

Random Blood Glucose

A

Sample from Nonfasting state

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13
Q

Hemoglobin A1c

A

Average blood glucose levels over last 2-3 months

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14
Q

Lipid Flagging Limits
- Total Cholesterol
- HDL
- Literally Everything Else

A
  • Should be low
  • Should be high
  • Should be low
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15
Q

INR: PT / Control

A

High = Clots too slow

Low = Clots too fast

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16
Q

Cardiac Injury Lab Values

A

Cardiac Proteins
- Troponin I, High Sense
- Troponin T, High Sense

Cardiac Kinase
- Creatine Kinase MB

17
Q

Prothrombin Time

A

How long it takes for blood to clot
- Helps access liver function
- Measures more factors than PTT

Extrinsic

18
Q

Fasting Blood Glucose

A

No food consumed in last 8 hours

19
Q

Partial Thromboplastin Time

A

Measure how long it takes for blood to clot

Used to monitor effects of unfractionated heparin

Intrinsic (Excludes Factor VII and XIII)
- Measures less factors than PT

20
Q

Adrenal Excess
- Symptoms

A
  • Weight Gain
  • Redistribution of Fat
  • Hypertension
  • Hirsutism
21
Q

Cushing’s DIsease
(Excess Glucocorticoid Steroid Use)

A

Low ACTH
Low Cortisol

22
Q

Coagulation Process

A

Platelet Activation
- Forms a plug
Fibrin Formation
- Platelet release clotting factors, creates fibrin, stabilizes plug, creates insoluble clot

23
Q

Causes of Creatine Kinase Increase

A

Skeletal
- Vigorous Exercise, Trauma, Rhabdomyolysis

Cardiac
- Myocarditis, Acute Myocardial Infarction

24
Q

Drugs that affect thyroid function (7)

A

Lithium
Amiodarone
Carbamazepine
Corticosteroids
Oral Contraceptives
Phenytoin
Propranolol

25
Q

Different kinds of Creatine Kinase

A

BB - Brain
MB - Cardiac Tissue
MM - Cardiac and Skeletel

26
Q

Adrenal Insufficiency (6)
- Symptoms

A
  • Weakness
  • Lethargy
  • Fatigue
  • Anorexia
  • Weight Loss
  • Hypoglycemia
27
Q

Kinds of lipoproteins

A

HDL: Remove cholesterol
- Good
LDL: Moves fat and some protein
- Bad
VLDL: Moves triglycerides
- Bad

28
Q

Hyperthyroidism Lab Values

A

Low TSH
High T4

29
Q

Platelet Conditions

A

Thrombocytopenia
- Low Platelet

Thrombocytosis
- High Platelet

30
Q

Signs and Symptoms of Adrenal Insufficiency

A

Weakness, Lethargy, Fatigue, Anorexia, Weight Loss, Hypoglycemia

31
Q

Addison’s Disease
- Kind of condition
- Lab Values

A

Adrenal Insufficiency
- Adrenal glands dont release cortisol

High ACTH
Low Cortisol

32
Q

T3 vs T4

A

T4 more abundant
T3 more potent

33
Q

Coagulation Conditions

A

Vitamin K Deficiency
- Malnutrition
- Fat Malabsorption
- Anticoagulants (Warfarin)

34
Q

Activated Partial Thromboplastin Time

A

Addition of an activator to accelerate clotting time

35
Q

Signs and Symptoms of Adrenal Excess

A

Increased body weight, Redistribution of body weight. Hypertension, Hirsutism

36
Q

Extrinsic vs Intrinsic Path

A

Extrinsic
- Prothrombin Time
Intrinsic
- Partial Thromboplastin Time

37
Q

Drugs and Conditions that affect Adrenal Values

A

Corticosteroids, Estrogen, Spironolactone

Pregnancy, Severe injury, Physical/Emotional stress

38
Q

Lipid Panel

A

Directly Measured
- Total Cholesterol
- HDL
- Triglycerides
- Apoprotein B

Calculated
- Non-HDL-C
- LDL

PHARM 343 (20 decks)

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