Stroke 3 Flashcards
reversal is only possible in what type of stroke?
ischaemic
only if done v quick
other than this, can only do secondary prevention to prevent another stroke
2 hyperacute treatments for ischaemic stroke?
thrombolysis (<4.5 hrs)
thrombectomy (<6 hrs)
types of secondary prevention?
antiplatelets anticoagulants statins anti hypertensives diabetic management lifestyle management MDT approach to rehab
how do you choose secondary prevention?
determine what caused initial stroke and prevent it happening again
most important risk factor for stroke?
hypertension
types of antiplatelets?
aspirin
clopidogrel
dipyridamole MR
ticagrelor and prasugrel (not used much in stroke disease)
when are antiplatelets used?
only ischaemic stroke
small vessel events and atheroembolic infarcts/TIAs
risks of antiplatelets after ischaemic stroke?
haemorrhagic transformation
will cause inflammation and oedema which causes problems
what kinds of ischaemic stroke are antiplatelets used for?
only ones where clot has formed due to platelet aggregation rather than coagulation factors
how is aspirin used after ischaemic stroke?
300mg for at least 2 weeks
after 2 weeks can either continue aspirin but drop down to 75mg along and add dipyrimadole 200mg 2X day OR change to clopidogrel 75mg alone
what if genuine allergy to aspirin?
clopidogrel 300mg straight after stroke (single dose) then 75mg thereafter (clopidogrel much more potent)
if patient had smaller stroke with low neurological score, which option is used?
aspirin + clopidogrel
what kind of ischaemic strokes are anti-coagulants used for?
large vessel cardioembolic paradoxical embolic venous infarcts (only clots formed of coagulation factors, not formed within arteries)
types of anticoagulants?
heparin (fractioned and unfractioned)
warfarin
DOACs (factor 10 or factor 2 inhibitors)
is heparin used in stroke?
no
increases bleeding risk too much
most common stroke requiring A/C?
cardioembolic (from AF)