Stroke Flashcards

1
Q

Sub-categorisation of Ischaemic strokes by aetiology

A

Atherosclerotic (in-situ)
* Large vessel
* Small vessel

Artery to artery embolism
* Extracranial vessel stenosis
* Dissection

Cardioembolic

Paroxysmal Embolism

Other

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2
Q

RFs Haemorrhagic stroke

A
  • HTN
  • Hypocholesterolemia
  • Heavy EtOH use
  • Cerebral amyloid angiopathy
  • Antithrombotic therapy
  • Underlying structural pathology
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3
Q

Where does ASA come off of

A

Vertebral arteries

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4
Q

Where does PICA come off of

A

Vertebral arteries

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5
Q

Order of cerebellar arteries (post/inf to sup/ ant)

A

PICA
AICA
SCA

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6
Q

Where does AICA come off of

A

Basilar artery

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7
Q

Anterior Cerebral artery syndrome

A
  • Leg>Arm/Face
  • Motor&raquo_space;sensory
  • Dysexecutive, abulia, urinary incontinence
  • Dysphasia (dominant)
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8
Q

Posterior Cerebral Artery syndrome

A
  • Homonymous Haemianopia
  • Behavioural change, memory issues
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9
Q

Middle cerebral artery syndrome

A
  • Face/Arm > Leg
  • Dysphasia (dominant)
  • Dyspraxia/Neglect (non-dominant)
  • Homonymous Haemianopia
  • Motor and Sensory
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10
Q

Basilar Artery/vertebral artery syndrome

A
  • Locked in syndrome (sparing EOM)
  • Initially vertigo, ataxia, diplopia, isolated limb symptoms
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11
Q

Small vessel/ lacunar stroke syndromes (5)

A
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12
Q

Gerstmann syndrome brain area

A

Inferior parietal lobule of dominant hemisphere

Angular and supramarginal gyri (Brodman area 39 and 40) near the temporal and parietal junction

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13
Q

Gerstman syndrome Sx

A
  • Dysgraphia/agraphia
  • Dyscalculia/acalculia
  • Finger agnosia
  • Left-right disorientation
  • +/- aphasia
  • +/- apraxia
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14
Q

Lateral Medullary syndrome synonyms

A
  • Wallenberg Syndrome
  • PICA syndrome
  • Vertebral artery syndrome - misnomer really as can cause other issues
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15
Q

Lateral Medullary syndrome Sx

A

Contralateral
* trunk/limb numbness (pain/temp)

Ipsilateral
* Facial numbness (pain/temp)
* Skew deviation/room tilt
* Dysphagia/hoarseness/gag
* Horner’s syndrome
* Limb ataxia

  • Palatal myoclonus
  • Vertigo/nystagmus
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16
Q

Top of the Basilar Syndrome

A
  • Ptosis
  • Dilated pupils
  • Ocular motor deficits
  • Somnolence (thalamic infarction), hallucinations, dreamlike behaviour
  • Motor function otherwise preserved

Can cause full basilar thrombosis -> locked in

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17
Q

Balint syndrome

A
  • B/L parietal/occipital junction lesions e.g. watershed
  • Simultagnosia
  • Oculomotor apraxia
  • Optic ataxia
18
Q

Anton syndrome

A
  • Bilateral occipital lesions
  • Cortical blindness
19
Q

Benedikt syndrome,

Webber syndrome

A
  • Midbrain stroke
  • Posterior cerebral artery or penetrating branches of basilar artery
  • CN III palsy
  • Ataxia/choreoathetosis

Webber syndrome
* Similar to Benedikt except more hemiplegia than limb ataxia

20
Q

Anterior spinal artery syndrome

A
  • Loss of power distally
  • +/- Loss of temp/pain
  • Posterior column unaffected
21
Q

Spinal cord syndrome with syringomyelia

A

Central cord syndrome

22
Q

Location of haemorrhage in cerebral amyloid angiopathy

A

Lobar Haemorrhage

23
Q

Location of haemorrhages in deep haemorrhages

A

B: Basal Ganglia
C: Thalamus
D: Pons
E: Cerebellum

(A is a lobar haemorrhage)

24
Q

Main RF for lobar cerebral haemorrhage

A

Cerebral amyloid angiopathy

25
Main RF for deep cerebral haemorrhage
HTN
26
ICH treatment
Lower blood pressure to ~140 systolic Reverse anticoagulation Surgical interventions * Posterior-fossa – most evidence of benefit * Supratentorial – no clear benefit unless declining; primarily reduces mortality * New microsurgeries hold some promise – ongoing clinical trials Determine underlying cause
27
Mian Ros for SAH
aneurysm, smoking, hypertension, female, methamphetamines, cocaine
28
SAH Px
* Thunderclap Headache * Photophobia, neck stiffness, confusion, focal neurology, seizures
29
Ix for SAH
* Head CT ideally with CTA (rarely conventional angiogram now) – 98.7% sensitive <6 hrs * Lumbar puncture for xanthrochromia (develops 12 hours post HA) (+ RBCs in the 100s to 1000s in 3% of people with normal CT) * MRI with SWI - maybe better than LP even really
30
SAH treatment
* ABC * Lower BP (SBP <140) to prevent rebleeding * Clip/coil aneurysm to fix the underlying problem * Oral Nimodipne to prevent vasospasm
31
Occlusion areas amenable to ECR
32
CI to thrombolysis (Bleeding risk)
*Known history of ICH *Prior stroke or serious head injury within 3months *Sustained Blood Pressure >185/110 *Dabigatran within 48 hrs/high TT/unable to give idarucizumab *Heparin within the last 48hrs with elevated PTT *PT >15seconds *Platelet count <100,000 uL *Major surgery within past 14days *Gastrointestinal or urinary tract hemorrhage within 21d *Arterial puncture at noncompressible site <7days
33
Strongest modifiable RF for stroke?
HTN
34
Anti-paltelets after stroke
DAPT for 21 days then SAPT
35
Stein with best evidence for stroke prevention?
atorvastatin
36
PSK9i in stroke prevention
Evolocumab good
37
Dose reduction criteria dabigatran
Use reduced dose of 110mg dose if * >80 years of age * CrCl 30-50 mL/min and HAS-BLED score is щ3, * between 75-80 years of age with a low CHA2 DS2 -VAS c score and HAS-BLED щ2, If CrCl <30ml/min DO NOT USE
38
Dabigatran reversal
Idarucizumab (praxbind)
39
CEA indication post stroke
CEA if symptomatic (<3/12) and * Ipsilateral 70-99% stenosis * Ipsilateral 50-69% stenosis in highly selected cases and low surgical risk (<3%)
40
PFO closure indications
Cryptogenic stroke/ TIA PFO on bubble study in 6-9 months Preferably young (<60)
41
Left atrial appendage occlusion
* May be considered in high stroke risk with genuine contraindication to anticoagulants