Myasthenia and Upper Limb Neuro

Question 1

Demographics MG

Answer 1

Swaps around from females while younger, males as older

Question 2

Conditions associated with anti AChR

Answer 2

MG

hyperthyroidism,
SLE,
scleroderma,
RhA

Question 3

Antibodies in MG

Answer 3

anti AChR (80%)

anti MuSK (20% of remaining 20%)

Question 4

MG subtypes

Answer 4

Question 5

MuSK negative/AChR AB negative MG

Answer 5

Tend to be milder than AChR AB positive cases, but otherwise similar.

Question 6

MusK Mg

Answer 6

HLA DR14-DQ5 association

Limb muscles often less affected

Progresses to severe facial and bulbar weakness, with atrophy of affected muscles.

Ritux more effective