Midgut Flashcards
Monitoring test in fulminant hepatic failure
PT/INR the best lab to monitor status (up to four times per day)
- Extensive and complete lab evaluation
- Doppler ultrasonography of the liver
Transplant criteria for fulminant hepatic failure
Acetaminophen induced liver failure
* Arterial pH <7.30
OR
* Grade 3 or 4 encephalopathy with PT>100seconds and Cr>340 mg/L
Non-acetaminophen induced liver failure
* PT>100 seconds
OR
* Any three of :
* Age <10 or >40 years
* Non-A and non-B viral hepatitis, idiosyncratic drug reaction, Wilson
* Jaundice >7 days prior to encephalopathy
* PT>50 seconds
* Bilirubin >180 mg/L
Reservoir for Hep A
only in humans
hep A % -> fulminant liver failure?
< 1% (usually if already have liver disease)
hep B % -> fulminant liver failure?
0.1-0.5% -due to massive immune-mediated lysis of infected hepatocytes (often DNA negative)
HBV extra-hepatic manifestations
in 20%
* Polyarteritis nodosa
* Glomerular disease (membranous nephropathy, MPGN, nephrotic syndrome)
* Serum sickness (arthritis, rash)
HBV treatment criteria
- Anyone with cirrhosis
- Immune active chronic HBV
Maybe (guidelines changing)
* HBV DNA >2000 IU/ml (HBeAg neg) with ALT 2x ULN
* HBV DNA >20,000 IU/ml (HBeAg pos) with ALT 2x ULN
HBV that doesn’t need treatment
- Immune tolerant phase (HBeAg positive, High DNA, normal transaminases)
- Inactive carrier phase (low or no DNA, normal transaminases)
- Latent HBV infection (DNA without HBsAg)
Which HBV treatment safe if preggers?
Lamivudine
HCV viral halflife?
~ 45 mins
Percent of acute HCV -> Chronic -> Cirrhosis
60-85% to chronic
20-30% with chronic to cirrhosis (over 20-30 years)
Extra-hep manifestations HCV
Cognitive impairment independent of liver disease stage
Lichen planus
* 19% with lichen planus will have HCV
* Six fold rise in risk for HCV in persons with lichen planus
* a T-cell mediated autoimmune disorder in which inflammatory cells attack an unknown protein within the skin and mucosal keratinocytes.
Essential Mixed Cryoglobulinemia
- Half of persons with HCV will have cryoglobulins
- Leukocytoclastic vasculitis
- Arthralgias
- Membranoproliferative glomerulonephritis
- Neurologic disease, peripheral neuropathy
Porphyria Cutanea Tarda
(a rare disorder characterized by painful, blistering skin lesions that develop on sun-exposed skin (photosensitivity))
Porphyria Cutanea Tarda
* Decreased activity of uroporphyrinogen decarboxylase
* May be inherited or acquired
* Sun exposed skin changes
* Elevated urine uroporphyrin levels
* 50% of those with PCT have HCV
HEV transmisison
- RNA virus transmitted in water/feces
- Highest incidence in Asia, Africa, Middle East, and Central America
- Animal reservoir (rodents, deer, boar)
- Acute disease in nonimmunocompromized patients
- Chronic disease in those with transplants
Fulminant HEV?
- Fulminant hepatic failure in 15-25 % in women who are pregnant