Epilepsy

Question 1

New term for partial seizures

Answer 1

Focal seizures (+/- secondary generalised)

Question 2

Etiology Seizured

Answer 2

Question 3

most common anti-epileptic MOA

Answer 3

block voltage gated Na Channels

Question 4

Preferred anti-seizure agents

Answer 4

Generalised:
- valproate (man)
- lamotrigine (1st in women)

Focal:
- no longer carbamazepine
- now lamotrigine

Question 5

Leviteracitam MOA

Answer 5

Synaptic vesicle protein 2A, inhibition Ca 2+ currents

Question 6

Topiramate MOA

Answer 6

AMPA and kainite receptor blocker (Na/ K/ Ca channel)

Question 7

Levetiracitam MOA

Answer 7

?? SV2A

Question 8

Vigabatran MOA

Answer 8

anti GABA

Question 9

barbiturate MOA

Answer 9

GABA receptor

Question 10

Leviteracitam interactions

Answer 10

• Doesn’t interact with other AED drug targets
• No interactions with the oral contraceptive / warfarin

Question 11

AE Leviteracitam

Answer 11

Fatigue, thrombocytopaenia, blurred vision, memory, personality, irritability, mood swings

– Suicidality vs. placebo (0.43 vs 0.22%)

Question 12

mTOR inhibitors

Answer 12

Everolimus and Sirolimus

Question 13

Specific AE for topioromate

Answer 13

attention & language

Question 14

HLA subtypes -> rash in epilepsy

Answer 14

– HLA B*1502 CBZ induced SJS

– HLA A *3101 CBZ induced rash

Question 15

Anti E to use in pregnancy

Answer 15

lamotrigine

All dose dependent so still try to decrease the dose as able

Question 16

Drug interaction lamotrigine and valporate

Answer 16

work better together, but more rash

Question 17

Drug interaction OCP to Lamotrigine

Answer 17

reduced Sz control

Question 18

Anti-epileptic drug level monitoring

Answer 18

Reasonable evidence for phenytoin, others not so much

Can be used to assess toxicity or adherence still though