Glomerulonephritis Flashcards

1
Q

Renal sources of antigens

A
  • Normalconstituents– Goodpasture Ag,componentsof podocyte– antiPLA2 Rantibody.
  • Nonͳrenalselfantigenslocalised inglomeruli– SLE,IgAͳIgGor cryoglobulins.
  • Exogenousantigens.Localise accordingtocharge&size.
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2
Q

Immune complex mediated GN

A

Post infectious
Membranoproliferative
GN (chronic infection)
IgA nephropathy

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3
Q

GNs from in situ immune deposit formation to exogenous antigens

A

Lupus nephritis
post-infectious GN
2ndary membranous

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4
Q

GNs from in situ immune deposit formation endogenous antigens

A

Anti-GBM GN
Membranous

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5
Q

CD4TcellsmostimplicatedinthepathogenesisofGN

A

Th17 cells

differnetiate in presence of TGFɵ,IL6

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6
Q

Investigations/ diagnostic algorhythm for proliferative GNs

A

IF microscopy, type of Ig

If no immune stuff: ANCA

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7
Q

Risk factors for ANCA vasculitidies

A
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