Glomerulonephritis Flashcards
1
Q
Renal sources of antigens
A
- Normalconstituents– Goodpasture Ag,componentsof podocyte– antiPLA2 Rantibody.
- Nonͳrenalselfantigenslocalised inglomeruli– SLE,IgAͳIgGor cryoglobulins.
- Exogenousantigens.Localise accordingtocharge&size.
2
Q
Immune complex mediated GN
A
Post infectious
Membranoproliferative
GN (chronic infection)
IgA nephropathy
3
Q
GNs from in situ immune deposit formation to exogenous antigens
A
Lupus nephritis
post-infectious GN
2ndary membranous
4
Q
GNs from in situ immune deposit formation endogenous antigens
A
Anti-GBM GN
Membranous
5
Q
CD4TcellsmostimplicatedinthepathogenesisofGN
A
Th17 cells
differnetiate in presence of TGFɵ,IL6
6
Q
Investigations/ diagnostic algorhythm for proliferative GNs
A
IF microscopy, type of Ig
If no immune stuff: ANCA
7
Q
Risk factors for ANCA vasculitidies
A