STOMACH Flashcards
Layers of the Stomach
MUCOSA - first and innermost layer
SUBMUCOSA - 2nd layer
- rich in branching blood vessels, lymphatics, collagen, various inflammatory cells, and nerve fibers
- Meissner’s autonomic submucosal plexus
- gives strength to GI anastomoses
MUSCULARIS EXTERNA (muscularis propria) - 3rd layer
-consists of an incomplete inner oblique layer
-a complete middle circular layer (continuous with the esophageal circular muscle and the circular muscle of the pylorus)
-a complete outer longitudinal layer (continuous with the longitudinal layer of the esophagus and
duodenum)
-Auerbach’s myenteric plexus
-interstitial cells of Cajal (ICC)
-specialized pacemaker cells
SEROSA (visceral peritoneum)
- last and outermost layer
- provides significant tensile strength to gastric anastomoses
- when tumors originating in the mucosa penetrate and breach the serosa, microscopic or gross peritoneal metastases are common, presumably from shedding of tumor cells that would not have occurred if the serosa had not been penetrated
Innervation of the Stomach
Parasympathetic: vagus nerve (CN X)
Sympathetic: celiac plexus (T5-T12)
Opening into the lesser sac
Foramen of Winslow
Parietal cells
HCl
IF
Chief cells
pepsinogen
Mucous neck cells
bicarbonate
mucus
G cells
gastrin
Location of G cells
antrum
Pepsin
Proteolytic enzyme that hydrolyzes peptide bonds
Protein secreted by the parietal cells that combines with vitamin B12 and allows
for absorption in the terminal ileum
Intrinsic Factor (IF)
GERD
Excessive reflux of gastric contents into the esophagus, “heartburn or pyrosis”
Branch that the POSTERIOR VAGUS sends to the posterior FUNDUS
Criminal nerve of Grassi
Heartburn
substernal burning type discomfort
beginning in the epigastrium and radiating upward
often aggravated by meals, spicy or fatty foods, chocolate, alcohol, and coffee
can be worse in the supine position
Effortless return of acid or bitter gastric contents into the chest, pharynx, or mouth
Regurgitation
GERD management
Small meals
PPIs (proton-pump inhibitors) or H2 blockers
Elevation of head at night and no meals prior to sleeping