ONCOLOGY

Question 1

TUMOR MARKERS

Answer 1

Alpha-Fetoprotein (AFP) - liver cancer, germ cell tumors
b-HCG - choriocarcinoma, germ cell tumors
BRCA-1 and BRCA-2 breast cancer, ovarian cancer
BCR-ABL fusion gene CML, ALL, AML
BRAF v600 mutation cutaneous melanoma,colorectal cancer, thyroid cancer
c-KIT/CD 117 GIST, cutaneous melanoma
CA 15-3/CA 27.29 breast cancer
CA 19-9 pancreatic cancer, gallbladder cancer, bile duct cancer, gastric
CA 125 ovarian cancer
calcitonin medullary thyroid cancer
CEA colorectal cancer
CD20 NHL
chromogranin A neuroendocrine tumors
cytokeratin fragment 21-1 lung cancer
EGFR gene mutation non small cell lung cancer
ER or PR breast cancer
fibrin/fibrinogen bladder cancer
HER2 or neu gene breast cancer, gastroesophageal junction carcinoma, gastric
KRAS gene colorectal cancer, non small cell lung cancer
LDH germ cell tumor, leukemia, lymphoma, melanoma, neuroblasto
PSA prostate cancer

Question 2

COMMON CHEMO PROTOCOLS

Answer 2

ABVD Hodgkin`s Lymphoma Adriamycin (Doxorubicin) Bleomycin
Vinblastine
Dacrabazine

AC breast cancer Adriamycin (Doxorubicin)
Cyclophosphamide

BEP testicular tumors, Bleomycin
germ cell tumor Etoposide
Platinum agent

CAPOX colon and rectal cancer Capecitabine
Oxaliplatin

FOLFOX colon and rectal cancer Folinic acid (Leucovorin)
5-FU
Oxaliplatin

ECF esophageal and gastric ca Epirubicin
Cyclophosphamide
5-FU

MAID soft tissue sarcomas Mesna
Adriamycin (Doxorubin)
Ifosfamide
Dacarbazine

R-CHOP	NHL								Rituximab
												Cyclophosphamide
												Hydroxydaunorubicin
												Oncovin (Vincristine)
												Prednisone