Stomach Flashcards

1
Q

Name 3 things that stimulate gastrin release and 2 functions of gastrin.

A

Proteins, distension and neural input

Gastric acid secretion
Stimulate mucosal growth

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2
Q

Give 5 functions of CCK.

What cells is it secreted from and where are these cells found?

What stimulates its release?

A
Gallbladder contraction
Pancreatic secretion stimulation 
Growth of exocrine pancreas
Inhibition of appetites
Slowing of gastric emptying. 

I cells in the duodenum and jejunum.

Fat and protein in the duodenum and proximal jejunum.

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3
Q

Name 2 things which stimulate secretin release and 4 functions of secretin.

A

H+ and fatty acids

Increases HCO3- secretion from pancreas and gallbladder
Decreases gastric acid secretion
Stimulates pepsin secretion
Growth of the exocrine pancreas

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4
Q

Name 3 functions of GIP.

A

Stimulates insulin secretion
Decreased gastric acid secretion
Mild effect in slowing gastric emptying.

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5
Q

What is the difference between the orad and caudad regions of the stomach in terms of contraction?

A

Orad - Upper Stomach - basal tone with sustained contractions

Caudad - strong peristaltic contractions every 20 seconds (3-5 times per minute)

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6
Q

What are the major components of gastric juice?

A

HCl, pepsinogen, IF and mucous.

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7
Q

What are the main cells in the pyloric glands of the antrum of the stomach?

What do these cells make?

A

G cells and mucous neck cells

G cells - gastrin

Mucous cells - mucus, pepsinogen and g HCO3-

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8
Q

What is the action of omeprazole?

A

H K ATPase inhibitor

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9
Q

What is the action of cimetidine?

A

Blocks H2 receptors on parietal cells

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