Stomach Flashcards
Name 3 things that stimulate gastrin release and 2 functions of gastrin.
Proteins, distension and neural input
Gastric acid secretion
Stimulate mucosal growth
Give 5 functions of CCK.
What cells is it secreted from and where are these cells found?
What stimulates its release?
Gallbladder contraction Pancreatic secretion stimulation Growth of exocrine pancreas Inhibition of appetites Slowing of gastric emptying.
I cells in the duodenum and jejunum.
Fat and protein in the duodenum and proximal jejunum.
Name 2 things which stimulate secretin release and 4 functions of secretin.
H+ and fatty acids
Increases HCO3- secretion from pancreas and gallbladder
Decreases gastric acid secretion
Stimulates pepsin secretion
Growth of the exocrine pancreas
Name 3 functions of GIP.
Stimulates insulin secretion
Decreased gastric acid secretion
Mild effect in slowing gastric emptying.
What is the difference between the orad and caudad regions of the stomach in terms of contraction?
Orad - Upper Stomach - basal tone with sustained contractions
Caudad - strong peristaltic contractions every 20 seconds (3-5 times per minute)
What are the major components of gastric juice?
HCl, pepsinogen, IF and mucous.
What are the main cells in the pyloric glands of the antrum of the stomach?
What do these cells make?
G cells and mucous neck cells
G cells - gastrin
Mucous cells - mucus, pepsinogen and g HCO3-
What is the action of omeprazole?
H K ATPase inhibitor
What is the action of cimetidine?
Blocks H2 receptors on parietal cells