Liver And Biliary Tree Pathology Flashcards
Give 2 specific symptoms of alcoholic hepatitis.
Rapid onset jaundice Tender hepatomegaly (RUQ pain)
Which Hep is more likely to have symptoms during acute infection?
Hep B
What is the inheritance pattern for hereditary haemochromatosis?
Autosomal recessive
What is a possible complication of hereditary haemochromatosis?
Hepatocellular carcinoma development
What is the treatment for Wilson’s disease?
Cheating agents (penicillamine)
Zinc
Liver transplant if progression to renal failure
Describe the difference in pathophysiology between PSC and PBC.
PSC - fibrosis of intra and extrahepatic bile ducts
PBC - destruction of the intrahepatic bile ducts
What diseases may be associated with PSC and PBC?
PSC - hepatobilliary malignancy (cholangiocarcinoma) and UC
PBC - RA
Describe the venous drainage of the rectum and explain how this correlates to it being a site for varices to occur.
Superior middle and inferior rectal veins
Superior - IMV - spleen - portal
Middle - internal iliac
Inferior - internal pudendal - internal iliac
Porto-systemic anastomoses
Back log due to portal hypertension can occur here
What is hepatorenal syndrome?
AKI in the presence of cirrhosis
In acute cholecystitis what can be seen on US.
Gall stones
Thick gall bladder wall
Describe the difference in pain between biliary colic and acute cholecystitis.
Both RUQ pain but in biliary colic pain sudden, dull and colicky and is precipitated buy the consumption of fatty foods.
Acute cholecystitis pain is consistent due t inflammation
What are the key signs and symptoms of acute pancreatitis?
Epigastric pain radiating to the back
Cullen’s sign - oedema and bruising around umbilicus
Grey turner’s sign - flank bruising
Nausea and vomiting
