Stimulant Pharma

Question 1

PLANT DERIVED STIMULANTS

Answer 1

cocaine
ephedra
khat

Question 2

SYNTHETIC STIMULANTS

Answer 2

amphetamine
methamphetamine
canthinone

Question 3

COCAINE METABOLITES

Answer 3

• > benzoylecgonine

- >ecgonine methyl ester

Question 4

COCAINE METABOLISM

Answer 4

ESTERASE
by carboxylesterases in the liver and by butyrylcholinesterase in the liver, plasma, brain, lung and other
remaining 5% is N-demthylated to norcocaine by CYP3A4 enzyme of cytochrome P450 system

Question 5

AMPHETAMINE METABOLISM

Answer 5

• DEAMINATION TO INACTIVE
• OXIDATION TO NOREPHEDRINE AND OTHER ACTIVE
• PARA-HYDROXYLATION TO ACTIVE

amphetamine is N-demethylated metabolite of methamphetamine

Question 6

STIMULANT DRUG DRUG INTERACTION

Answer 6

MAO inhibitor within two weeks

also caution with TCA’s (block synaptic reuptake of catecholamines)

Question 7

STIMULANT MECHANISM

Answer 7

enhance extracellular concentrations of monoamine nurotransmitters (DA. NA, 5-HT3) by disrupting plasma membrane transporters
cocaine and methylphenidate - reuptake blockers (transporter blockers)
amphetamine and phentermine - releasers (transporter substrates)

Question 8

MONOAMINE NEUROTRANSMITTERS

Answer 8

dopamine, noradrenaline and serotonin