ALCOHOL PHARMA Flashcards

1
Q

STD ALCOHOLIC DRINK

A
0.6oz alcohol =
=12 oz beer
=5 oz wine
=1.5 oz distilled spirits (40%)
blood alcohol levels fall 20mg/dl/h
body clears 1oz/3hours
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2
Q

ALCOHOL ENZYMES

A

EtOH — (ADH) —> acetaldehyde — (acetaldhyde dehydrogenase) —> acetate
broken down by alcohol dehydrogenase (ADH) and mixed function oxidases such as P45011E1 (CYP 2E1)

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3
Q

METADOXINE

A

enhances metabolic clearance of alcohol

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4
Q

ALCOHOL CNS DEPRESSANT

ADDITIVE EFFECTS BY

A
barbiturates
benzos
general anesthetic
volatile organic solvents
anticonvulsives
antihistamines
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5
Q

ALCOHOL ENHANCES

A

acetaminophen - hepatotix

NSAIDS - GI

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6
Q

MOLECULAR SITES OF ALCOHOL ACTION

A

GABA and glycine receptors
glutamate activated ion channels
5-HT3 receptors
acetylcholine nicotinic receptors
adenosine triphosphate gated ion channels
potassium and calcium selective ion channels

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7
Q

ALCOHOL ACTION ON NEUROTRANSMITTERS

A
adenosine
dopamine (VTA DA neurons -> DA release in nucleus accumbent, prefrontal cortex +)
opioids and other neuropeptides
serotonin
endocannabinoids (CB1)
neuroimmune modulators
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8
Q

ALCOHOL TOXICITY STATES

A

low levels (10-50mg%) dec anxiety, incr well being, socialness
mod (80-100) impaired judgement/motor function
higher (150-200) ataxia, reduced reaction, blackout
anesthetic (300-400) severe motor impairment, vomiting, loss of consciousness
lethal (400-500) and above

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