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ASAM Essentials Addiction Medicine > Caffeine/Tobacco Pharma > Flashcards

Caffeine/Tobacco Pharma Flashcards

1
Q

CAFFEINE RECEPTORS

A

antagonism of adenosine receptors and indirect effects on dopaminergic neurotransmission

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2
Q

CAFFEINE METABOLISM

A

cytochrome P450
half life:
increased by cigarettes
decreased by liver disease, OCPs, infants and pregnancy

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3
Q

NICOTINE STEADY STATE LEVELS

A

10-50 ng/mL

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4
Q

NICOTINE METABOLISM

A

to cotinine in liver brain and lung
cytochrome P450 2A6 (CYP2A6)
woman>men
aa 30% greater nicotine/cigarette

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5
Q

COTININE BLOOD LEVELS

A

250-300ng/mL in regular smokers persist for 7 d

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6
Q

NICOTINE DRUG INTERACTIONS

A

induce metabolism of theophylline, propranolol, flecainide, tacrine, caffeine, olanzapine, clozapine, imipramine, haloperidol, pentazocine, estradiol plus

less sedation from benzos, less analgesia from some opioids

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7
Q

NICOTINE ACTIONS

A

ligand gated ion channels nAChRs

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ASAM Essentials Addiction Medicine (17 decks)

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