Hallucinogen/Dissociative PHARMA

Question 1

CLASSICAL HALLUCINOGENS

Answer 1

mescaline
psilocybin
lysergic acid (LSD)
demithyltryptamine (DMT)

Question 2

ENTACTOGENIC PHENYLALKYLAMINES

HALLUCINOGENS

Answer 2

MDMA (methylenedioxyamphetamine 3,4-methylenedioxymethamphetamine)
methylenedioxyethylamphetamine

Question 3

ANTICHOLINERGIC DISSOCIATIVES

HALLUCINOGENS

Answer 3

atropine
hyoscyamine
scopolamine

Question 4

DISSOCIATIVE ANESTHETICS

HALLUCINOGENS

Answer 4

phencyclidine
ketamine
salvinorin A

Question 5

Classical hallucinogens receptors

Answer 5

affinity for 5-HT receptors, also can interact with DA

Question 6

INDOLEALKYLAMINE HALLUCINAGENS

Answer 6

relatively non selective for 5-HT receptors

Question 7

SALVIA/SALVINORUM RECEPTOR

Answer 7

κ-opioid receptor agonist

Question 8

MDMA

Answer 8

entactogen

release reuptake inhibition of dopamine and noradrenaline

Question 9

DISSOCIATIVE RECEPTORS

Answer 9

glutamic acid N-methyl-D-aspartate (NMDA) receptors

Question 10

DISSOCIATIVES

Answer 10

arylcyclohexamines

• PCP
• ketamines
• dizocilpine (MK-801)
• dextromethorphan (DXM)
• nitrous oxide

Question 11

NITROUS OXIDE ACTION

Answer 11

stimulate release of endogenous opioid

Question 12

KETAMINE ACTION

Answer 12

antagonism of NDMA receptor -> block excitation of GABA interneurons ->removal of GABAergic inhibition of cholinergic, serotinergic and glutametergic afferents to posterior retrosplenial cingulate cortex