STI

Question 1

N. Gonorrhea

Answer 1

gram neg diplococci in urethra or cervical exudate
-diagnostic in men urethra.
aerobic, requires 3% CO2 on chocolate or thayer martin agar
-oxidase positive, maltose non-fermentor

Question 2

who get infected with GC

Answer 2

eye infections in neonates
preadolescent females are very vulnerable due to abuse
women can be ASX

Question 3

GC infection in men

Answer 3

urethritis, dysuria, discharge

complication–> acute epididymitis

Question 4

GC infection in women

Answer 4

urethritis, cervicitis, discharge, PID, fallopian tube scarring

Question 5

what type of tissue does gonorrhea adhere best to ?

Answer 5

columnar over squamous

Question 6

virulence factor of GC

Answer 6

pilus- initiates binding
-undergoes antigenic variation
-undegoes phase variation- on/off switch
OPA protein
-undergoes antigenic variation
-undegoes phase variation- on/off switch

Question 7

abx resistance

Answer 7

beta lactamse picked up from Ecoli

cipro resistance

Question 8

treatment for gonnorhea

Answer 8

IM ceftriaxone and Azithromycin

Question 9

Chlamydia characteristics

Answer 9

oblogate intracellular
gram - cocci
-changes forms between entry bodies and reticulate bodies
-giemsa stain, lugol stain

can cause inclusional conjunctivits

Question 10

chlamydia pathogenicity

Answer 10

Adhesins- attachment

Inhibit phagolysosome maturation

Heat labile toxin

can cause latent infections

Question 11

symptoms in men of Chlamydia

Answer 11

urethritis
discharge
epididymitis
proctitis
urethral stricturing
DIC
reactive arthritis

Question 12

symptoms in women

Answer 12

discharge
acute urethral syndrome
cervicitis
PID
tubal infertility
ectopic pregnancy
bartholinitis
perihepatitis

Question 13

What is most common cause of neonatal conjunctivitis

Answer 13

Chlamydia, treat with amox or macrolide for prevention

Question 14

what is cause of lymphogranuloma venereum?

Answer 14

genital ulcers and lymphadenopathy cause by L1-L2 types of chlamydia

Question 15

Syphilis

Answer 15

treponema pallidum
cant be cultured
spirochete
reproduce by transverse fission
4 stages of syphilis
iv penicillin
herxeimer rxn

Question 16

Syphilis Dx

Answer 16

darkfield microscope on chancre

RPR card test followed by Treponemal tests (e.g., FTA-ABS)

Question 17

congenital syphilis

Answer 17

huthcinsons teeth
mulberry molars
short maxilla
saber shins
CN8 deafness
rhagades facies-creases around mouth

Question 18

4 stages of syphilis

Answer 18

1. chancre, regional lymphadenopathy, infectious
   serology may be negative
2. rash palms and soles
   condylomata lata, alopecia
   serology positive
3. gummas, aortitis, neurosyphilis, Argyll Robertson pupil (accomadates but doesnt dilate, small pupils), ataxia
4. latent