intro 2

Question 1

post antibiotic effect

Answer 1

occurs only with bacteriocidal agents

delay of regrowth of bacteria after use of antibiotics

Question 2

2. Describe the pharmacokinetic factors in the selection of antibiotic therapy.

Answer 2

1

Question 3

3. Explain the importance of host factors in the selection of antibiotic therapy.

Answer 3

1

Question 4

4. Discuss the major restricting toxicities important in the selection of antimicrobial therapy.

Answer 4

1

Question 5

5. Discuss the main uses of all antibiotics for bacteria and diseases where antibiotics are warranted.

Answer 5

1

Question 6

6. For each drug class, describe the drug targets, mechanism of action and resistance, basis for selective toxicity, general pharmacokinetics, major restricting toxicities, general spectrum of activity, and main uses.

Answer 6

1

Question 7

7. For each of the “bolded” drugs on the distributed drug list describe the drug targets, mechanism of action and resistance, basis for selective toxicity, general pharmacokinetics, major restricting toxicities, general spectrum of activity, and main uses.

Answer 7

1

Question 8

Penicillins

Answer 8

inhibit cell wall synthesis
renal excretion
Anaphylaxis (1)
rash(3)
convulsions high dose

Question 9

Pen G

Answer 9

IV IM poor oral
gram +/- cocci
gram + bacilli
most anaerobes

Question 10

Pen V

Answer 10

good oral
gram +/- cocci
gram + bacilli
most anaerobes

Question 11

Methicillin, Oxacillin

Answer 11

Penicillinase resistant
IV/IM, oral
use on beta lactamase producing staph aureus

Question 12

Ampicillin, amoxicillin (w/ beta lactamase inhibitor i.e. clav)

Answer 12

extended spectrum
good oral
GI upset
Enterobacter, H flu, Ecoli

Question 13

Piperacillin (w/ Beta lactamse inhibitor)

Answer 13

IV only

less positive, more negative bacteroides, psuedomonas