herpes viruses

Question 1

herpes genome

Answer 1

dsdna enveloped

Question 2

life cycle

Answer 2

attach-> entry-> uncoating-> gene expression->genome replication, virion assembly

Question 3

what are the alpha herpes viruses

where are they latent?

Answer 3

HSV, VAricella zoster

sensory neurons

Question 4

what are the beta herpes viruses

where are they latent?

Answer 4

CMV, HHV-6, HHV-7

myeloid cells

Question 5

what are the gamme herpes viruses

where are they latent?

Answer 5

EBV, KSV (kaposi sarcoma)

B-cells

Question 6

what are targets for the apative immune response on herpes viruses

Answer 6

viral glycoproteins

Question 7

what are the inclusions for alpha viruses

Answer 7

intrannuclear- cowdrie A bodies acidophilic

Question 8

what are the inclusions for Beta viruses

Answer 8

intranuclear- owl eyes, basophilic

intracytoplasmic CMV, HHV-6

Question 9

viral actions against host response

Answer 9

decoy receptors

FC binding proteins–> block dendrictic cels

Question 10

HSV-1

Answer 10

latency in TG ganglion

• rarely causes encephalitis
• above the belt
• prodrome
• antiviral not standard of care
• primary infection is the worst

Question 11

complications of HSV-1

Answer 11

encephalitis, hepatic keratitis, gingival stomatitis

Question 12

HSV-2

Answer 12

lumbosacral ganglions, rarely cause meningitis
below the belt
ASX shedding

Question 13

HSV-2 complications

Answer 13

urethritis, memingitis, yeast superinfection, perirectal diease

Question 14

HSV lesion natural hx

Answer 14

papule- vesicle-pustule, scab

Question 15

Varicella

Answer 15

primary is chicken pox
secondary is zoster shingles
respirarory secretions

Question 16

zoster life cycle

Answer 16

replication in primary lymph nodes–> viremia–> spleen/liver–>viremia–> skin–> rash–> retrograde to DRG

Question 17

chicken pox characteristics

Answer 17

crops in different stages 3-5 days
dew drops on a rose pedal
infectious untilo scabbbing

Question 18

Diagnosis of chicken pox

Answer 18

PCR

Question 19

Tx-

Answer 19

vaccination for those over 60

Question 20

complications of VZV

Answer 20

bacterial superinfection
encephalitis
congenital VZV
severe in immunocompromised

Question 21

dermatomlal reactivation

Answer 21

prodrome
vesicular rash in dermatomal distribution
post herpetic neuralgia

Question 22

shingles therapy

Answer 22

acyclovir +/- steroids

Question 23

CMV

Answer 23

beta virus, latent in bone marrow progenitors
CD34+
inflammatory stimuli can reactivate virus

Question 24

who is at risk for CMV

Answer 24

transplant from donor + recipient negative
-all recieve prophylaxis or monitoring
perinatal- maternal shedding in birth canal or MILK
childhood- minor
adoleascent mono like
immunocompromised- can be severe

Question 25

what is most common new born viral infection and what are its signs

Answer 25

CMV Jaundice, microcephaly, low platent, HSM reflects maternal immune status

Question 26

Tx for Beta herpes viruses

Answer 26

gangcyclovir if needed | if resistent foscarnet

Question 27

hhv-6, HHV-7

Answer 27

Roseola, 6th disease, extanthem subitum infects tonsilar, and salivary B and T cells Hgh fever for 3-7 days, followed by a rash on trunk face and extrmeities

Question 28

complications of HHV-6 and HHV-7

Answer 28

febrile seizures, end organ dieases in the immunocompromised

Question 29

gamma herpes viruses

Answer 29

EB virus, HHV-8 (kaposi)

Question 30

EBV

Answer 30

infectious mono latency in naive B cells--> can be reactivated when B cell activates can have a big spleen symptoms are caused by T cells destroy infected B cells clinical diagnoses, monospot not that specific

Question 31

EBM symptoms

Answer 31

fever, pharyngitis, malaise, HSM, Adenopathy

Question 32

what does EBNA do?

Answer 32

links viral genome to cellular chromosome

Question 33

what does EBNA-2 do

Answer 33

turns on genes like c-myc

Question 34

EBV associated malignancy

Answer 34

``` -post transplant lymphoproliferative disorder (lack of CTL) Burkitt lymphoma B cell lymphoma leiomyosarcoma hodgkin lymphoma nasopharyngeocarcinoma gastricadenocarcinoma ```

Question 35

Kaposi sarcoma Herpes virus (HHV-8)

Answer 35

``` hiv associated dark spots on skin considered STD, also spread in saliva clogs up lymphatics latent in B cells associated with lymphoma ```