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Infectious Disease > herpes viruses > Flashcards

herpes viruses Flashcards

1
Q

herpes genome

A

dsdna enveloped

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2
Q

life cycle

A

attach-> entry-> uncoating-> gene expression->genome replication, virion assembly

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3
Q

what are the alpha herpes viruses

where are they latent?

A

HSV, VAricella zoster

sensory neurons

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4
Q

what are the beta herpes viruses

where are they latent?

A

CMV, HHV-6, HHV-7

myeloid cells

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5
Q

what are the gamme herpes viruses

where are they latent?

A

EBV, KSV (kaposi sarcoma)

B-cells

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6
Q

what are targets for the apative immune response on herpes viruses

A

viral glycoproteins

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7
Q

what are the inclusions for alpha viruses

A

intrannuclear- cowdrie A bodies acidophilic

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8
Q

what are the inclusions for Beta viruses

A

intranuclear- owl eyes, basophilic

intracytoplasmic CMV, HHV-6

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9
Q

viral actions against host response

A

decoy receptors

FC binding proteins–> block dendrictic cels

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10
Q

HSV-1

A

latency in TG ganglion

  • rarely causes encephalitis
  • above the belt
  • prodrome
  • antiviral not standard of care
  • primary infection is the worst
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11
Q

complications of HSV-1

A

encephalitis, hepatic keratitis, gingival stomatitis

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12
Q

HSV-2

A

lumbosacral ganglions, rarely cause meningitis
below the belt
ASX shedding

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13
Q

HSV-2 complications

A

urethritis, memingitis, yeast superinfection, perirectal diease

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14
Q

HSV lesion natural hx

A

papule- vesicle-pustule, scab

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15
Q

Varicella

A

primary is chicken pox
secondary is zoster shingles
respirarory secretions

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16
Q

zoster life cycle

A

replication in primary lymph nodes–> viremia–> spleen/liver–>viremia–> skin–> rash–> retrograde to DRG

17
Q

chicken pox characteristics

A

crops in different stages 3-5 days
dew drops on a rose pedal
infectious untilo scabbbing

18
Q

Diagnosis of chicken pox

A

PCR

19
Q

Tx-

A

vaccination for those over 60

20
Q

complications of VZV

A

bacterial superinfection
encephalitis
congenital VZV
severe in immunocompromised

21
Q

dermatomlal reactivation

A

prodrome
vesicular rash in dermatomal distribution
post herpetic neuralgia

22
Q

shingles therapy

A

acyclovir +/- steroids

23
Q

CMV

A

beta virus, latent in bone marrow progenitors
CD34+
inflammatory stimuli can reactivate virus

24
Q

who is at risk for CMV

A

transplant from donor + recipient negative
-all recieve prophylaxis or monitoring
perinatal- maternal shedding in birth canal or MILK
childhood- minor
adoleascent mono like
immunocompromised- can be severe

25
Q

what is most common new born viral infection and what are its signs

A

CMV
Jaundice, microcephaly, low platent, HSM
reflects maternal immune status

26
Q

Tx for Beta herpes viruses

A

gangcyclovir if needed

if resistent foscarnet

27
Q

hhv-6, HHV-7

A

Roseola, 6th disease, extanthem subitum
infects tonsilar, and salivary B and T cells

Hgh fever for 3-7 days, followed by a rash on trunk face and extrmeities

28
Q

complications of HHV-6 and HHV-7

A

febrile seizures, end organ dieases in the immunocompromised

29
Q

gamma herpes viruses

A

EB virus, HHV-8 (kaposi)

30
Q

EBV

A

infectious mono
latency in naive B cells–> can be reactivated when B cell activates
can have a big spleen
symptoms are caused by T cells destroy infected B cells
clinical diagnoses, monospot not that specific

31
Q

EBM symptoms

A

fever, pharyngitis, malaise, HSM, Adenopathy

32
Q

what does EBNA do?

A

links viral genome to cellular chromosome

33
Q

what does EBNA-2 do

A

turns on genes like c-myc

34
Q

EBV associated malignancy

A 
-post transplant lymphoproliferative disorder (lack of CTL)
Burkitt lymphoma
B cell lymphoma
leiomyosarcoma
hodgkin lymphoma
nasopharyngeocarcinoma
gastricadenocarcinoma
35
Q

Kaposi sarcoma Herpes virus (HHV-8)

A 
hiv associated
dark spots on skin
considered STD, also spread in saliva
clogs up lymphatics
latent in B cells
associated with lymphoma

Infectious Disease (12 decks)

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