Antibiotics Flashcards
1
Q
Flouroquinolones MOA adverse USes route/excretion static/cidal
A
inhibition of bacterial DNA gyrase interacts with theophylline avoid antacids avoid in children excellent gram neg more positivws with levo and moxi bacteriocidal
2
Q
Aminoglycosides MOA adverse USes route/excretion static/cidal
A
30s subunit, bacteriocidal, poor oral
ototoxicity, nephrotoxicity
med spectrum
3
Q
Teracyclines MOA adverse USes route/excretion static/cidal
A
30 s subunit, staic and cidal, bone
tooth and bone issues in kids, superinfections
broad spectrum
4
Q
Macrolides MOA adverse USes route/excretion static/cidal
A
50 s subunit static/cidal
concentrates in lungs
CYP450 inhibiters
med spectrum
5
Q
Chloramphenicol MOA adverse USes route/excretion static/cidal
A
50 s static
grey baby syndrome, bone marrow toxicity
brod spctrum
hepatic met
6
Q
Clindamycin MOA adverse USes route/excretion static/cidal
A
Lincosamide, 50s, static, penetrates bone
hepatic
severe diarrrhea, psuedomembraneous colitis
narrow spectrum gram + cocci
7
Q
Synercid MOA adverse USes route/excretion static/cidal
A
Streptogramin, 50s hepatic, CYP 34A inhibitor
VREF
8
Q
Oxazolidinones MOA adverse USes route/excretion static/cidal
A
50s hepatic
inhibits MAOI–> tyramine rxn
VREF, MSSA, MRSA, strep
9
Q
TRM-SMX MOA adverse USes route/excretion static/cidal
A
inhibits folic acid met bacteriostatic hypersentivity, kernicterus in kids hepatic broad spectrum
10
Q
Nitrofurantoin MOA adverse USes route/excretion static/cidal
A
DNA damaging, static, renal excretion, only oral, hypersensitivity gi upset
UTI bugs
11
Q
MEtronidazole MOA adverse USes route/excretion static/cidal
A
degrades DNA, bacteriocidal
stops metabolism of ethanol
amoeba, c.dd, ecoli
