Steven Johnson's Syndrome Flashcards
What is Steven Johnson’s syndrome?
-potentially fatal acute skin disorder
how is Steven Johnson’s syndrome characterized?
widespread erythema and macule formation resulting in epidermal detachment or sloughing and erosion formation
Steven Johnson’s syndrome mortality rate
1-5%
what can trigger Steven Johnson’s syndrome?
medication reactions
what medications trigger Steven Johnson’s syndrome?
sulfonamides, anticonvulsants, NSAIDs, allopurinol, oxicam
Steven Johnson’s syndrome risk factors
-medications
-weakened immune system (Cancer & HIV)
-history of SJS
-family history of SJS
-genetic factors
Steven Johnson’s syndrome clinical manifestations
Initially:
-burning or itching
-tenderness
-flu-like symptoms (fever, cough, sore throat, headache, severe malaise, aches/pains)
Followed by:
-rapid onset of erythema involving much of the skin surface and mucous membranes
-Large bull develop or large sheets of epidermis are shed
-excruciatingly tender, loss of skin leaves a weepings surface like a total body partial thickness burn
Steven Johnson’s syndrome Complications
-keratoconjunctivitis (inflammation of cornea and conductive) - impairs vision, scarring, corneal lesions
-dehydration
-respiratory failure
-sepsis
-MODS
-permanent skin damage
Steven Johnson’s syndrome Management
-control of fluid and electrolyte balance
-prevention of sepsis and ophthalmic complications
-transfer to burn center
-medications: IVIG (IV immunoglobulin - blood product prepared from serum), cyclosporin, cyclophosphamide
-wound care
Steven Johnson’s syndrome nursing interventions
-maintain skin & mucous membrane integrity
-attain fluid balance
-preventing hypothermia
-relieve pain
-reducing anxiety
-monitor and manage potential complications
-education