Stem cells Flashcards
Self renewal
Ability to divide and produce more stem cells
Potency
capacity to differentiate into various cell types
Totipotent
All body cells or placental (zygote->morula)
Pluripotent
All cells but placental (inner cell mass-blastocyst)
Multipotent
More restricted cells (germ layers)
Oligopotent
Limited number (lymphoid stem cell)
Unipotent
Produce only 1 cell type (muscle stem cell)
Describe Embryonic stem cells
Pluripotent, early stage embryos, inner cell mass
Describe Adult stem cells
Multipotent, found in various tissues
Induced stem cells
Pluripotent, regular adult cells reprogrammed
Transition of embryonic stem cells to cell types
Intrinsic and extrinsic factors (insert image)
Hematopoietic (ASC)
Blood cells, In bone marrow, multipotent
Mesenchymal (ASC)
Cells of Mesodermal lineage (connective/skeletal), In bone marrow + adipose tissue, multipotent
Neural (ASC)
Nervous system cells, In brain and spinal cord, multipotent
Epithelial (ASC)
Epithelial tissues, In epithelial tissues (skin/lungs), unipotent or multipotent
Skin (ASC)
Skin/hair, basal layer epidermis, multipotent
Epithelial tissue germ layers
Ectoderm, mesoderm, endoderm
Muscle tissue germ layers
Mesoderm
Nervous tissue germ layers
Ectoderm
Connective tissue germ layers
Mesoderm
Ectoderm organs
Skin, nervous system, mammary glands, pituitary gland
Mesoderm organs
Skeletal , muscular, circulatory, excretory, reproductive, dermis of skin, adrenal cortex
Endoderm organs
Digestive system, respiratory system, endocrine glands, urinary system, epithelial parts of pharynx
Skin-germ layer
ectoderm
