Stem cells Flashcards
Self renewal
Ability to divide and produce more stem cells
Potency
capacity to differentiate into various cell types
Totipotent
All body cells or placental (zygote->morula)
Pluripotent
All cells but placental (inner cell mass-blastocyst)
Multipotent
More restricted cells (germ layers)
Oligopotent
Limited number (lymphoid stem cell)
Unipotent
Produce only 1 cell type (muscle stem cell)
Describe Embryonic stem cells
Pluripotent, early stage embryos, inner cell mass
Describe Adult stem cells
Multipotent, found in various tissues
Induced stem cells
Pluripotent, regular adult cells reprogrammed
Transition of embryonic stem cells to cell types
Intrinsic and extrinsic factors (insert image)
Hematopoietic (ASC)
Blood cells, In bone marrow, multipotent
Mesenchymal (ASC)
Cells of Mesodermal lineage (connective/skeletal), In bone marrow + adipose tissue, multipotent
Neural (ASC)
Nervous system cells, In brain and spinal cord, multipotent
Epithelial (ASC)
Epithelial tissues, In epithelial tissues (skin/lungs), unipotent or multipotent