STATINS Flashcards
1
Q
When are statins used?
A
1’ prevention of CVD (high QRISK2 score)
2’ prevention of CVD
Hypercholesterolaemia
2
Q
ADRs of statins
A
headache, GI disturbance
muscle aches > myopathy > rhabdomyolysis
rise in liver enzymes > risk of drug induced hep
3
Q
Cautions using statins
A
hepatic impairment - can accumulate > ADRs
renal impairment
4
Q
Monitoring statins
A
LFTs (AST/ALT) + lipid profile
5
Q
Interactions of statins with other drugs
A
CP450 inhibitors = reduce breakdown of statins = accumulation > risk of myopathy
