ANTIHYPERTENSIVES

Question 1

ADRs of CCBs

Answer 1

hypotension, palpitations, peripheral oedema, flushing
(dont use in HF patients)

bradycardia, heart block

Question 2

ADRs of BBs

Answer 2

hypotension, bradycardia, wheeze/bronchospasm, impotence

Question 3

ADRs of ACEis

Answer 3

hypotension, dry cough, hyperkalaemia, renal impairment/AKI

Question 4

What electrolyte abnormalities are seen with ACE-is?

Answer 4

Hyperkalaemia
Hyponatraemia (lack of aldosterone, no Na+ retention)

Question 5

Avoid which two combinations of antihypertensives?

Answer 5

CCBs + BBs

Question 6

Interactions of ACEis

Answer 6

Avoid with NSAIDs - worsens renal function/nephrotoxic

K+ elevating drugs - risk of hyperkalaemia

Question 7

Administration instructions of ACEis

Answer 7

Take in evening/PM as risk of postural hypotension

Question 8

ACEis monitoring

Answer 8

Check electrolytes (K+) and renal function (U/Es and creatinine) before Rx and after dose change

Titrated up to therapeutic level

Question 9

ACEis and pregnancy

Answer 9

teratogenic = AVOID!!

Question 10

Contraindications of BBs

Answer 10

Avoid in asthmatics (bronchospasm + wheeze)