OPIATES

Question 1

ADRs of strong opioids

Answer 1

• respiratory depression
• euphoria + detachment
• N+V*
• pupillary constriction
• constipation*
• drowsiness*

tolerance + dependence

Question 2

Caution with opioid use

Answer 2

hepatic and renal impairment
elderly
respiratory failure

Question 3

Strong opioid interactions

Answer 3

should not be used with other sedating drugs e.g.

• TCA
• BZDs
• antipsychotics

Question 4

Patient communication

Answer 4

• N+V = antiemetic (metoclopramide)
• stimulant laxative = Senna
• ++ hydration

Question 5

Tramadol and seizures

Answer 5

Lowers sz threshold - avoid in its with epilepsy

Question 6

Weak opioid administration

Answer 6

• weak opioids mainly given orally (or IM)
• avoid operating machinery, driving etc if drowsy
• if compound given, avoid other paracetamol containing products (max 4g/day - prescription r/v)