DRUGS, ADRs AND TOXICITY Flashcards
Nephrotoxic drugs
Abx - tetracyclines, vancomycin, gentamicin
NSAIDs - constrict AA
ACE-is - dilate EA
Which drugs can cause SIADH?
carbamazepine
SSRIs
ADRs of gentamicin and vancomicin
nephrotoxic and ototoxic
Drugs that cause hypoNa
loop, thiazide and K+ diuretics
SSRIs - citalopram, sertraline, duloxetine
Drugs that cause hyperNa
Lithium
Phenytoin
Drugs that cause hyperK
ACEis + K+ sparing diuretics
ARBs
Risk of hypokalaemia
Torsade de pointes
Drugs that cause hypoK
`loop diuretics, thiazide diuretics
Which drugs require monitoring?
Lithium Theophyline Digoxin Gentamicin Vancomicin Phenytoin
Features of digoxin toxicity
Confusion, arrythmias, nausea, visual haloes
Features of lithium toxicity
Early: tremors
Intermediate: confusion, tiredness
Late: seizures, renal failure, coma, arrythmias
Features of phenytoin toxicity
Gum hypertrophy, ataxia, nystagmus, peripheral neuropathy
Antidotes
- Opiates
- Paracetamol
- BZDs
- naloxone
- NAC
- flumazenil
