Statins Flashcards

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1
Q

What are the only class of lipid-lowering drugs that definitely reduce CV risk?

A

Statins

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2
Q

How do statins work?

A

HMG-CoA reductase inhibitors

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3
Q

What is the most potent statin?

A

Rosuvastatin

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4
Q

What is the least potent statin?

A

Pravastatin

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5
Q

Which statins are metabolised by CYP450?

A

Simvastatin

Atorvastatin

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6
Q

What is the biggest SE of statins?

A

Skeletal muscle toxicity- rhabdo in extreme cases

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7
Q

What are other SEs of statins?

A

Renal toxicity, GI disturbance, sleep disturbance, erectile dysfunction

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