IBD Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

What IV steroids are used in severe IBD?

A

Hydrocortisone

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2
Q

What oral steroids are used in severe IBD?

A

Prednisolone

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3
Q

What are some e.gs of 5-ASA meds?

A

Balsalazide, mesalazine, sulfasalazine

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4
Q

What are rare SEs of 5-ASA meds?

A

Blood dyscrasias- any patients reporting bruising, bleeding, sore throat should have an urgent FBC performed

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5
Q

How does azathioprine work?

A

Pro-drug converted to 6-mercaptopurine

Metabolised by thiopurine methyltransferase- low activity level associated with increased risk of toxicity

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6
Q

When are biologics used in IBD?

A

Refractory (unresponsive) disease

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7
Q

How do biologics work?

A

Mab which inhibit TNF-a

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8
Q

What are some e.gs of biologics?

A

Infliximab
Adalimumab
Golimumab

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9
Q

What are the adverse effects of biologics?

A

Immunosuppression- increased risk of infection, autoimmunity and malignancy

Reactivation of TB (CXR before starting)

Increased risk autoimmunity and ?malignancy

Infliximab- rarely life threatening hypersensitivity (resusc equipment!)

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10
Q

Mx UC?

A

Limited- enemas, suppositories

Extensive- systemic treatment. Once controlled give 5-ASA

Severe unresponsive- ciclosporin, infliximab

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11
Q

Mx Crohns?

A

Active- corticosteroids. Azathioprine or methotrexate as steroid-sparing agents

Anti-TNFs- active and maintenance

Often need surgery at some point

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12
Q

Mx strictures ass with Crohns?

A

Treatment with abx- ciprofloxcin or metronidazole

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