Epilepsy Flashcards
1st line mx of generalised tonic-clonic seizures?
Carbamazepine
Lamotrigdine
Sodium valproate
Oxcarbazepine
What is the mx of tonic or absence seizures?
Sodium valproate
What epilepsy meds are enzyme inducers?
Carbamazepine (reduces efficacy other AEDs)
Phenytoin (reduces efficacy other AEDs)
Sodium valproate (increases level of other AEDs)
Topiramate (weak inducer)
Oxcarbazepine (weak inducer)
What epilepsy meds are susceptible to enzyme inducers?
Lamotrigine
Tiagabine
Levetiracetam
What is first line mx of absence seizures?
Ethosuximide
Lamotrigine
Sodium valproate
What is second line for tonic-clonic seizures?
Clobazepam Lamotrigine Sodium valproate Levetiracetam Topiramate
What are the SEs of carbamazepine?
Strong enzyme inducer- affects other AED and OCP.
Reduced bone density
Auto induction
What are the SEs of phenytoin?
Strong enzyme inducer- affects other AED and OCP.
Susceptible to other inducers
Reduced bone density
What drug interactions does gabapentin have?
None significant
What drug interactions does levetiracetam have?
None significant
What drug interactions does pregabalin have?
None significant
What are the rules for driving a car or motorcycle when epileptic?
1 year since last seizure before license allowed.
Not allowed during and for 6 months after medication has been changed
Once compliant with treatment driving allowed
What are the rules for driving an HGV, bus or large vehicle when epileptic?
No seizures for 10 years before licence granted
What anticonvulsants are safe in pregnancy?
Lamotrigine apparently safe
Folate supplementation essential
What AED should be absolutely avoided in pregnancy?
Sodium valproate
