SSRIs Flashcards
citalopram
celexa
escitalopram
lexapro
fluoxetine
prozac
fluvoxamine
luvox
paroxetine
paxil
sertraline
zoloft
MOA of SSRIs
increase serotonin activity by decreasing action of the presynaptic serotonin uptake pump
indications for SSRIs
- anxiety d/o (OCD, panic, SAD, PTSD, GAD)
- anorexia/bulimia nervosa
- premenstrual dysphroic disorder
- MDD, dysthymia
- with a mood stabilizer for bipolar depression
- some efficacy in pain syndromes (migraine or chronic pain)
- may be effective in impulse control d/o and emotional physical symptoms of menopause
dosing of SSRIs
QDaily
is there a linear relationship between SSRI dose and response?
NO, don’t have to max out dose before switching drugs
which disorders require high dosing of SSRIs?
OCD, anorexia/bulimia nervosa (may even be BID)
which disorders only need low dosing of SSRIs?
panic
metabolism of SSRIs
CYP450 in the liver EXCEPT celexa and lexapro
time to steady state for SSRI?
5 days for everything but prozac (over a month)
how long until symptoms are alleviated from SSRIs?
2-4 weeks
how long should SSRI treatment be continued before it is considered refractory?
6-8 weeks
is the lack of a response to one SSRI predictive of effectiveness of another?
NOPE
is measuring plasma levels indicated for SSRIs?
NOPE
are SSRIs safe in overdose
YUP