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Behavioral Health > Atypical Antidepressants > Flashcards

Atypical Antidepressants Flashcards

1
Q

bupropion

A

wellbutrin

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2
Q

mirtazapine

A

remeron

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3
Q

role of atypical antidepressants

A
  • cannot tolerate SSRI
  • SSRI not effective
  • CAN be used as 1st line therapy
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4
Q

MOA of bupropion

A

structurally similar to amphetamine, some think it’s really a dopamine norepinephrine reuotake inhibitor

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5
Q

which neurotransmitter does buproprion have the greatest effect on?

A

dopamine

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6
Q

metabolism of buproprion

A

liver

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7
Q

indications for bupropion

A
  • MDD, dysthymia, bipolar depression
  • ADHD
  • SAD
  • low dose can help sexual dysfunciton with SSRIs
  • smoking cessation
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8
Q

side effects of bupropion

A

insomnia, QT prolongation, GI effects, CNS stim, HA, constipation, dry mouth, tremor, at high doses can exacerbate psychosis

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9
Q

is there an increased seizure risk in higher doses of bupropion?

A

YES

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10
Q

will bupropion raise BP in a hypertensive patient?

A

maybe

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11
Q

Who shouldn’t get Wellbutrin?

A

Not optimal for pts with anxiety

Contraindicated in pts with seizure or active eating disorder and in those on a MAOI

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12
Q

should bupropion be taken before bed?

A

probably not, some report stimulant like effect (duh it’s chemically similar to a stimulant)

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13
Q

can bupropion be taken during pregnancy?

A

NOPE

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14
Q

can bupropion be combined with prozac?

A

YES, it is actually the MOST effective and well tolerated treatment of all types of depression, BUT can exacerbate panic disorder

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15
Q

can bupropion give a false positive urine amphetamine?

A

YES

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16
Q

MOA of mirtazapine

A

structurally similar to tricyclic and tetracyclic antidepressants. NOT a reuptake inhibitor, antagonizes adrenergic and serotonin receptors

17
Q

does mirtazapine have an effect on histamine receptors?

A

YES, which explains why it is very sedating

18
Q

indications for mirtazapine

A

Refractory depression and anxiety disorders, especially in pts who need to gain weight

19
Q

side effects of mirtazapine

A

SEDATION, anticholinergic, QT prolongation, weight GAIN/increased appetite, sexual dysfunction

20
Q

what happens if mirtazapine is taken with benzos or alcohol?

A

potentiates sedation

21
Q

Trazodone

A

Desyrel

22
Q

Use of trazodone

A

Refractory major depression, depression with anxiety and insomnia

23
Q

side effects of trazodone

A

Nausea, dizziness, orthostatic hypotension, cardiac arrhythmia, sedation and priapism

24
Q

High vs low dose or remeron

A

Low dose: maximum sedative effect

High dose: increases norepinephrine uptake and is less sedating

Behavioral Health (15 decks)

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