Misc. Drugs Flashcards
flumazenil
romazicon
indication for romazicon
benzo overdose
MOA of romazicon
block/reverse CNS effects of benzos but NOT other sedatives like ETOH or barbituates
side effect of romazicon
n/v, dizziness, agitation and emotional lability
issue with romazicon
may initiate seizures
half life of romazicon
VERY short so sedation will often return
buspirone
buspar
MOA of buspar
serotonin 1A agonist
indication for buspar
GAD, augment tx for depression and OCD
benefit of buspar over benzos
lacks sedation and dependence
is there a withdrawal from buspar?
NOPE
what happens if a patient has taken benzos before and now is on buspar?
reduced effectiveness
time to symptom relief with buspar?
2-4 weeks
how many times is buspar dosed a day?
3 - short half life
hydroxyzine
atarax
MOA of atarax
antihistamine and anixolytic
indication for atarax
anxiety in the short term and sometimes to augment sedative effects of antipsychotics in acute agitation
is ther dependence associated with atarax?
NOPE
limit of atarax?
anticholinergic side effefcts
ramelteon
rozeram
MOA of rozeram
melatonin agonist
indication for rozeram
onset insomnia
who cannot get rozeram
liver insufficient patients
diphenhydramine
benadryl
indication of benadryl
little evidence that it improves insomnia
side effects of benadryl
anticholinergic and sedation the next day (long half life)
modanfinil
provigil
MOA of provigil
unknown, but probably increases domaminergic signaling
indications for provigil
narcolepsy and those who need to maintain wakefulness
comparison of provigil to amphetamines
equal effect on wakefullness, but provigil has less risk of excessive activation
