SR 27 - Surgical Infection Flashcards
Define cellulitus
Blanching erythema from superficial dermal/epidermal infection
Define a superinfection
New infection arising while a patient is receiving antibiotics for teh original infection at a different site
What is the most common nosocomial infection?
UTI
What is the most common nosocomial infection leading to death?
Respiratory tract infection (pneumonia)
What constitutes a positive urine analysis?
Positive nitrite
Positive leukocyte esterase
>10 WBC/HPF
Presence of bacteria (supportive)
What number of CFU confirms the diagnosis of UTI?
100,000 (10^5) CFU
What are the common organisms for UTI?
E. coli, klebsiella, proteus
Enterococcus, staphylococcus aureus
What is the treatment for UTIs?
Antibiotics with gram-negative spectrum (i.e. Bactrim, gentamicin, ciprofloxacin, aztreonam)
Check culture and sensitivity - adjust meds from there
What is the treatment for bladder candidiasis?
Remove or change foley catheter
Administer systemic fluconazole or give amphotericin bladder washings
What are the signs of a central line infection?
Unexplained hyperglycemia
Fever, mental status change, hypotension, tachycardia
Shock
Pus and erythema at central line site
What is the most common cause of ‘catheter-related bloodstream infections’?
Coagulase-negative staphylococcus (33%)
Enterococci, Staphylococcus aureus, gram-negative rods
When should central lines be changed?
When they are infected
There is NO advantage to changing them ever 7 days
What central line infusion increases the risk of infection?
Hyperal (TPN)
What is the treatmetn for central line infection?
Remove central line, send for culture
+/- IV antibiotics
Place new central line in a different place
When should peripheral IV short angiocatheters be changed?
Every 72-96 hours
What is a surgical site infection?
When do they arise?
Infection in an operative wound
POD 5-7
Signs and symptoms of surgical site infections?
Pain at incision site, erythema, drainage, induration, warm skin, fever
What is the treatment for surgical site infections?
Remove skin sutures/staples Rule out fascial dehiscence Pack wound open Send wound culture Administer antibiotics
What are the most common bacteria found in post-op wound infections?
Staph aureus (20%)
E. coli (10%)
Enterococcus (10%)
Others - staph epidermidids, pseudomonas, anaerobes, gram -, streptococcus
Which bacteria cause fever and wound infection in the first 24 hours after surgery?
Streptococcus
Clostridium (bronze-brown weeping tender wound)
What is the definition of a ‘clean’ wound? Infection rate?
Elective, nontraumatic wound without acute inflammation
usually closes primarily without the use of drains
What is the definition of a ‘clean-contaminated’ wound? Infection rate?
Operation on GIT or RT withou unusual contamination or entry into the biliary or urinary tract
What is the definition of a ‘contaminated’ wound? Infection rate?
Acute inflammation, traumatic wound, GIT spillage, or a major break in sterile technique
5% infection rate
What is the definition of a ‘dirty’ wound? Infection rate?
Pus present, perforated viscus or dirty traumatic would
33% infection rate
What are the possible complications of wound infections?
Fistula, sinus tracts, sepsis, abscess, suppressed wound healing, superinfection, hernia
What factors influence the development of infections?
Foreign body (i.e. suture, drains, grafts)
Decreased blood flow (poor delivery of PMNs and antibiotics)
Strangulation of tissues with excessively tight sutures
Necrotic tissue or excessive local tissue destruction
Long operation (>2 hrs)
Hypothermia in OR
Hematomas or seromas
Dead space that prevvents the delivery of phagocytic cells to bacterial foci
Poor approximation of tissues
What patient factors influence the development of infections?
Uremia Hypovolemic shock Vascular occlusive states Advanced age Distant area of infection
What are examples of an immunosuppressed state?
Immunosuppressant treatment Chemotherapy Systemic malignancy Trauma or burn injury Diabetes mellitus Obesity Malnutrition AIDS Uremia
What lab tests are indicated with a surgical wound infections?
CBC - leukocytosis or leukopenia (an abscess may act as a WBC sink)
Blood cultures
Imaging studies (i.e. CT scan to locate an abscess)
What is the treatment for surgical wound infections?
Incision and drainage - an abscess must be drained
Antibiotics for deep abscesses
What are the indications for antibiotic after drainage of a subcutaneous abscess?
DM, surrounding cellulitis, prosthetic heart valve or immunocompromised state
(flucuation is a sign of a subcutaneous abscess)
What are the causes of a peritoneal abscess?
Postoperative status after a laparotomy, ruptured appendix, peritonitis, any inflammatory intraperitoneal process, anastomotic leak