SPRING PCEUT EXAM 1

Question 1

Mechlorethamine

Answer 1

DNA crosslinker

Question 2

Cyclopohosphamide

Answer 2

DNA crosslinker

Question 3

Cisplatin

Answer 3

DNA crosslinker

Question 4

Methotrexate

Answer 4

competitive inhibitor of DHFR- stops supply of dTTP which stops DNA replication

Question 5

5-FU

Answer 5

competitive inhibitor of thymidylate synthase, supply of dTTP declines stopping DNA replication

Question 6

Thioguanine

Answer 6

inhibits purine biosynthesis and incorporates in DNA and RNA

Question 7

Cytarabine

Answer 7

incorporates into elongating DNA, blocking elongation and induces apoptosis

Question 8

Hydroxyurea

Answer 8

inhibits ribonucleotide reductase, depletes pools of dNTPS blocking DNA replication

Question 9

Irinotecan

Answer 9

Topoisomerase I inhibitor

Question 10

Doxorubicin

Answer 10

topoisomerase II inhibitor

Question 11

Etoposide

Answer 11

topoisomerase II inhibitor

Question 12

Actinomycin D

Answer 12

intercalates into GC rich DNA and blocks RNA Pol I

Question 13

Bleomycin

Answer 13

generates oxygen free radicals that cleave DNA

Question 14

Paclitaxel

Answer 14

arrest cells at metaphase

Question 15

vincristine

Answer 15

arrest cells at prometaphase

Question 16

Leuprolide

Answer 16

GnRH analog

Question 17

Anastrazole

Answer 17

aromatase inhibitor

Question 18

Abiraterone

Answer 18

CYP17A inhibitor

Question 19

Trastuzumab

Answer 19

block HER2

Question 20

Cetuximab

Answer 20

block EGFR

Question 21

Tamoxifen

Answer 21

SERM

Question 22

Fulvestrant

Answer 22

SERD

Question 23

Bevacizumab

Answer 23

binds and inactivates VEGF

Question 24

Sunitinib

Answer 24

inhibits VEGF receptor

Question 25

alemtuzumab

Answer 25

binds CD52

Question 26

rituximab

Answer 26

binds CD20

Question 27

basiliximab

Answer 27

binds IL-2 receptor

Question 28

belatercept

Answer 28

binds CD80 and CD86

Question 29

belimumab

Answer 29

binds human B lymphocyte stimulator

Question 30

imatinib

Answer 30

BCR-ABL

Question 31

crizotinib

Answer 31

ALK

Question 32

erlotinib

Answer 32

EGFR kinase

Question 33

osimertinib

Answer 33

EGFR kinase

Question 34

sotorasib

Answer 34

RAS

Question 35

palbociclib

Answer 35

CDK4

Question 36

bortezomib

Answer 36

26S proteasome

Question 37

lenalidomide

Answer 37

ubiquitin ligase

Question 38

olaparib

Answer 38

PARP

Question 39

rucaparib

Answer 39

PARP

Question 40

vemurafinib

Answer 40

BRAF

Question 41

Venetoclax

Answer 41

BCL-2 (anti-apoptotic protein) `