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Therapeutics > Exam 1 > Flashcards

Exam 1 Flashcards

1
Q

AOM 1st line therapy

A

No antibiotics within 30 days- Amoxicillin 90mg/kg divided q12h

Antibiotics within 30 days or severe symptoms- Amox-clav

Alternative: cefdinir 14mg/kg/day divided q12h

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2
Q

AOM Failed Therapy

A

Ceftriaxone 50mg/kg/day x3days

or

Clindamycin 30-40mg/kg/day divided q8h AND/OR cephalosporin

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3
Q

AOM Treatment Length

A

Under 2 yrs: 10 days
2-5yrs: 7 days
Over 6 yrs: 5-7 days
Adult: 10 days

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4
Q

ABS 1st line therapy

A

Amox-clav: 875/125- 1t q12h

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5
Q

ABS 2nd line therapy

A

Amox-clav: 1000/62.5- 2t q12h

Doxycycline: 100 mg bid

Clindamycin: 300-450 mg tid
AND
Cefpodoxime: 200mg bid

Levofloxacin: 750 mg daily

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6
Q

ABS Treatment Duration

A

Normal: 5-7 days
Severe: 7-10 days

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7
Q

Empiric Treatment of Meningitis

A

**1month-50yrs:
Ceftriaxone 2g IV q12h +
Vancomycin: 15-20mg/kg IV q8-12 hrs (2g loading dose and 1.25g q8-12hrs)

**Over 50yrs or complications: **
Ceftriaxone +
Vancomycin
+Ampicillin 2gIV q4h

Alternative:
Meropenem: 2g IV q8h

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8
Q

CAP, low risk, no comorbidities

A

Amoxicillin: 1g tid OR
Doxycycline: 100mg bid OR
Azithromycin: 500 mg x1 day, then 250mg x4days

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9
Q

CAP, low risk with comorbidities

A

Amox-clav: 875/125 1t bid OR
Cefpodoxime: 200mg bid OR
Cefuroxime: 500 mg bid

PLUS

Doxycycline 100mg bid OR
Azithromycin 500mg x1 day, then 250mg x4 days

OR JUST
Levofloxacin 750mg qd

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10
Q

CAP, high risk, not severe

A

Beta-lactam (ceftriaxone 1-2g IV q24h)

PLUS
Macrolide (azithromycin 500mg IV q24h)

OR
Doxycycline 100mg bid

OR FLUOROQUINOLONE MONOTHERAPY:
Moxifloxacin 400mg qd
Levofloxacin 750mg qd

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11
Q

CAP, high risk, severe

A

Beta-lactam (ceftriaxone 1-2g IV q24h)

PLUS
Azithromycin (500mg IV q24h)
OR
Fluoroquinolone

NO MONOTHERAPY

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12
Q

Amoxicillin AOM Dose

A

90mg/kg/day divided q12h

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13
Q

Cefdinir AOM Dose

A

14mg/kg/day divided q12h

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14
Q

Ceftriaxone AOM Dose

A

50mg/kg/day x3days

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15
Q

Clindamycin AOM Dose

A

30-40mg/kg/day divided q8h

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16
Q

Azithromycin AOM Dose

A

10mg/kg on first day
5mg/kg on days 2-5

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17
Q

Amox-Clav ABS Dose

A

875/125 1t bid
or
1000/62.5 2t bid

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18
Q

Doxycycline Dose

A

100mg bid

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19
Q

Clindamycin ABS Dose

A

300-450mg q8h

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20
Q

Levofloxacin ABS Dose

A

750mg qd

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21
Q

Ceftriaxone Meningitis

A

Ceftriaxone 2g IV q12h

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22
Q

Vancomycin Meningitis

A

Vancomycin: 15-20mg/kg IV q8-12 hrs (2g loading dose and 1.25g q8-12hrs)

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23
Q

Meropenem Meningitis

A

2g IV q8h

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24
Q

Ampicillin Meningitis

A

Ampicillin 2g IV q4h

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25
Q

CAP Amoxicillin

A

1g tid

26
Q

Cefpodoxime CAP

A

200mg bid

27
Q

Cefuroxime

A

500mg bid

28
Q

CAP Ceftriaxone

A

1-2g q24h

29
Q

Severe CAP Azithromycin

A

500mg IV q24h

30
Q

Moxifloxacin CAP

A

400mg qd

31
Q

Purulent Cellulitis

A

TMP-SMX: 2 DS Tablets q12h
Doxycycline: 100mg q12h
Vancomycin

32
Q

Non-purulent cellulitis

A

Cephalexin: 500 mg q6h
Dicloxacillin: 500mg q6h
Clindamycin: 300mg q8h

33
Q

Erysipelas

A

Penicillin G 1-2mu IV q6h

34
Q

Necrotizing Fasciitis

A

Piperacillin-tazobactam: 4.5g IV over 30mins then 3.375g IV over 4 hrs q8h

Linezolid: 600mg IV q12h

35
Q

HAP/VAP ,no mssa

A

Piperacillin-tazobactam
Cefepime
Levofloxacin
Imipenem/meropenem

36
Q

HAP/VAP, mrsa

A

Piperacillin-tazobactam
cefepime/ceftazidime
levofloxacin/ciprofloxacin
imipenem/meropenem
aztreonam

AND
Vancomycin
Linezolid

37
Q

HAP/VAP with risk factors

A

piperacillin-tazobactam
cefepime/ceftazidime
imipenem/meropenem
aztreonam

AND

Levofloxacin/ciprofloxacin
amikacin/gentamicin/tobramycolistin/polymixin B

AND
Vancomycin
linezolid

38
Q

Piperacillin-tazobactam dose

A

4.5g IV x1, then 3.375g IV q8h

39
Q

Cefepime dose HAP

A

2g IV q8h

40
Q

Ceftazidime HAP

A

2g IV q8h

41
Q

Imipenem HAP

A

500 mg q6h

42
Q

Meropenem HAP

A

1g q8h

43
Q

Amikacin HAP

A

15-20mg/kg q24h

44
Q

Gentamicin HAP

A

7mg/kg q24h

45
Q

Tobramycin HAP

A

7mg/kg q24h

46
Q

Ciprofloxacin HAP

A

400mg q8h

47
Q

Levofloxacin HAP

A

750mg IV q24h

48
Q

Colistin HAP

A

5mg/kg IV x1, then 2.5mg/kg q12h

49
Q

Polymixin B HAP

A

2.5-3mg/kg/day divided in 2 doses

50
Q

Linezolid HAP

A

600mg q12h

51
Q

Necrotizing Fasciitis if clostridium

A

penicillin G 3-4mu IV q4h
linezolid

if not clostridium, discontinue linezolid

52
Q

Uncomplicated UTI

A

Nitrofurantoin: 100mg bid x5days

TMP-SMX: 160/800 bid x3days

Fosfomycin: 3g single dose

53
Q

Complicated UTI

A

Levofloxacin: 750mg qd x5days

Ciprofloxacin: 500mg q12h x 7-14days

54
Q

Acute pyelonephritis

A

levofloxacin: 750mg IV/PO q24h x5-7days

ciprofloxacin: 400mg IV (500mg PO) q12h x5-7days

55
Q

Acute pyelonephritis and FQ resistance

A

Ceftriaxone 1g IV q24h x 10days

56
Q

Acute pyelonephritis resistant organism risk

A

cefepime 2g IV q8h
meropenem 1g IV q8h
ertapenem 1g IV q24

57
Q

Gonorrhea

A

<150kg: ceftriaxone 500mg IM x1

> 150kg: ceftriaxone 500mg IM x1

+(if chlamydia can’t be ruled out)
doxycycline 100mg bid x7days
or
azithromycin 1g po x1day (if pregnant)

58
Q

Chlamydia

A

doxycycline: 100mg bid x7days

Alternatives:
azithromycin 1g po x1
levofloxacin 500mg po q24h x7days

59
Q

syphilis

A

Benzathine penicillin G 2.4 mu IM x1

Late latent/tertiary:
Benzathine penicillin G 2.4 mu IM qwk x3 weeks

Neurosyphilis:
benzathine penicillin G 3-4 mu IM q4h x10-14days

60
Q

Herpes

A

first clinical episode:
-acyclovir 400mg PO tid x7-10 days
-famciclovir 250mg PO tid x7-10 days
-valacyclovir 1g PO bid x7-10 days

Recurrent infection:
-aciclovir 400mg bid
-valacyclovir 500mg/1g qd
-famiciclovir 250mg bid

Therapeutics (2 decks)

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