Splenomegaly Flashcards
presentation of enlarged spleen
dragging sensation in LUQ
discomfort when eating
pain if infarct
triad in hypersplenism
splenomegaly
fall in one or more cellular components
correction by splenectomy
infective causes of splenomegaly
EBV malaria TB lymphoid brucellosis leishmaniasis trypanosomiasis
congestion causes of splenomegaly
portal (hepatic cirrhosis, portal/ splenic vein thrombosis, cardiac failure)
haematological disease causes of splenomegaly
lymphoma/ leukaemia
haemolytic anaemias
ITP
myeloproliferative
inflammatory conditions that cause splenomegaly
RA
SLE
storage diseases that cause splenomegaly
Gaucher’s
Niemann-Pick disease
miscellaneous causes of splenomegaly
amyloid
tumours
cysts
most common cause of hyposplenism?
splenectomy
other causes of hyposplenism
Coeliac’s
sickle cell disease
sarcoidosis
iatrogenic
features of hyposplenism
Howell-Jolly bodies
red cell abnormalities from red pulp
role of the spleen
immune response
removal of old red cells
necessary for immunity against encapsulated organisms
