Haematological Cancers Physiology Flashcards
lifespan of a neutrophil
7-8 hours
what is a blast?
nucleated precursor cells (erythroblasts and myeloblasts)
platelet precursor
megakaryocyte
what regulates platelet production?
thrombopoietin, a glycoprotein produced by the liver and kidney
what is a reticulocyte?
immediate red cell precursor (polychromasia)
what is a myelocyte?
nucleated precursor between neutrophils and blasts
development events in haemopoiesis
self-renewal proliferation differentiation maturation apoptosis
define pluripotency
ability to differentiate into a specific type of lineage of blood cell
which layer of the embryo do HSC originate?
mesoderm
sites of haematopoiesis in the embryo
yolk sac
liver starts at week 6
bone marrow at week 16
when is the cellularity of bone marrow highest?
when born and decreases with age
IgM
recent infection
IgG
past infection
what are immunoglobulins?
antibodies produced by B cells from plasma cells
what are immunoglobulins made up of?
2 heavy (μ, α, δ, γ, ε) 2 light chains (κ or λ)