Lymphoma Flashcards
classification of lymphoma
- Hodgkin’s
2. NHL
risk factors for lymphoma
immunosuppression AI (sjogren's, Coeliac's) infections (EBV, H. pylori, HHV-8, HTLV-1) genetics environment
two types of hodgkin’s lymphoma
classical
non-classical
two types of NHL
B cell
T cell
presentation of lymphoma
lump
B symptoms= fever, night sweats, weight loss (10% over a 6-month period)
itch without rash
alcohol-induced pain
extra-nodal disease= renal failure, SVC obstruction, effusions, marrow failure
diagnosis of lymphoma
FBC biochemical profile (hypercalacemia) biopsy DEFINITIVE imaging immunophenotyping genetic analysis
what to do in biopsy of lymphoma?
excise whole node
positive is brown, negative is blue
what to give before biopsy in lymphoma?
steroids
genetic analysis methods in lymphoma
- PCR
2. FISH
genetic change in follicular lymphoma (chromosome translocation)
t(14;18)
genetic change in Burkitt’s lymphoma
t(8;14)
involves myc
which is the fastest growth lymphoma?
Burkitt’s (B cells)
what viruses are associated with Burkitt’s?
HIV
EBV
presentation of Burkitt’s
jaw/ abdominal tumour
fast growing
extra-nodal (bone marrow, testis)
what to be aware of in treatment of Burkitt’s?
tumour lysis
methods for staging lymphoma
CT
PET
staging system in lymphoma
Ann Arbor
describe the Ann Arbor staging
stage 1= 1 lymph node or extra-node area
stage 2= 2 or more on one side of diaphragm
stage 3= 2 or more on both sides of the diaphragm
stage 4= disseminated or multiple extra-nodal areas
what is prognostic in lymphoma?
LDH
presentation of Hodgkin’s lymphoma
3rd decade (young females) alcohol-induced pain
special associations in diagnosis of Hodgkin’s lymphoma
above diaphragm
Reed-Sternberg cell
management of Hodgkin’s lymphoma
multi-agent chemotherapy +/- radiotherapy
bleomycin
adverse of bleomycin
pneumonitis
what is the management of NHL?
multi-agent chemotherapy +/- radiotherapy
monoclonal Ab therapy + chemotherapy
autologous stem cell rescue or CART
monoclonal Ab used in B cell NHL
rituximab
monoclonal Ab used in T cell NHL
brentuximab