Lymphoma

Question 1

classification of lymphoma

Answer 1

1. Hodgkin’s

2. NHL

Question 2

risk factors for lymphoma

Answer 2

immunosuppression
AI (sjogren's, Coeliac's)
infections (EBV, H. pylori, HHV-8, HTLV-1)
genetics
environment

Question 3

two types of hodgkin’s lymphoma

Answer 3

classical

non-classical

Question 4

two types of NHL

Answer 4

B cell

T cell

Question 5

presentation of lymphoma

Answer 5

lump
B symptoms= fever, night sweats, weight loss (10% over a 6-month period)
itch without rash
alcohol-induced pain
extra-nodal disease= renal failure, SVC obstruction, effusions, marrow failure

Question 6

diagnosis of lymphoma

Answer 6

FBC
biochemical profile (hypercalacemia)
biopsy DEFINITIVE
imaging
immunophenotyping
genetic analysis

Question 7

what to do in biopsy of lymphoma?

Answer 7

excise whole node

positive is brown, negative is blue

Question 8

what to give before biopsy in lymphoma?

Answer 8

steroids

Question 9

genetic analysis methods in lymphoma

Answer 9

1. PCR

2. FISH

Question 10

genetic change in follicular lymphoma (chromosome translocation)

Answer 10

t(14;18)

Question 11

genetic change in Burkitt’s lymphoma

Answer 11

t(8;14)

involves myc

Question 12

which is the fastest growth lymphoma?

Answer 12

Burkitt’s (B cells)

Question 13

what viruses are associated with Burkitt’s?

Answer 13

HIV

EBV

Question 14

presentation of Burkitt’s

Answer 14

jaw/ abdominal tumour
fast growing
extra-nodal (bone marrow, testis)

Question 15

what to be aware of in treatment of Burkitt’s?

Answer 15

tumour lysis

Question 16

methods for staging lymphoma

Answer 16

CT

PET

Question 17

staging system in lymphoma

Answer 17

Ann Arbor

Question 18

describe the Ann Arbor staging

Answer 18

stage 1= 1 lymph node or extra-node area
stage 2= 2 or more on one side of diaphragm
stage 3= 2 or more on both sides of the diaphragm
stage 4= disseminated or multiple extra-nodal areas

Question 19

what is prognostic in lymphoma?

Answer 19

LDH

Question 20

presentation of Hodgkin’s lymphoma

Answer 20

3rd decade (young females)
alcohol-induced pain

Question 21

special associations in diagnosis of Hodgkin’s lymphoma

Answer 21

above diaphragm

Reed-Sternberg cell

Question 22

management of Hodgkin’s lymphoma

Answer 22

multi-agent chemotherapy +/- radiotherapy

bleomycin

Question 23

adverse of bleomycin

Answer 23

pneumonitis

Question 24

what is the management of NHL?

Answer 24

multi-agent chemotherapy +/- radiotherapy
monoclonal Ab therapy + chemotherapy
autologous stem cell rescue or CART

Question 25

monoclonal Ab used in B cell NHL

Answer 25

rituximab

Question 26

monoclonal Ab used in T cell NHL

Answer 26

brentuximab