Splenomegaly Flashcards

1
Q

most frequent causes of splenomegaly

A
  • reactive reticulo-endothelial hyperplasia in pts with chronic hemolytic anemia
  • lymphoid hyperplasia in spleen in pts with lymphoma
  • neoplastic proliferation of lymphoid cells
  • myelofibrosis
  • metastasis
  • vascular congestion in liver cirrhosis
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2
Q

classification of splenomegaly according to etiopathogenesis

A
  • congestive
  • infectious
  • inflammatory
  • infiltrative/neoplastic
  • infiltrative/non neoplastic
  • RBC destruction (chronic hemolytic anemia)
  • structure
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3
Q

repercussions on the CBC profile of hypersplenism

A

anemia, bleeding (thrombocytopenia), and infections (neutropenia)

  • pancytopenia
  • compensatory bone marrow hyperplasia
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4
Q

repercussions on the CBC profile of splenectomy

A

transient leukocytosis, thrombocytosis. Hypo-splenism could be a late consequence

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5
Q

pre splenectomy procedure you must give which vaccines

A

pneumococcum

streptococcum

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6
Q

indications for splenectomy

A
  • splenic trauma with splenic disruption
  • splenomegaly in myelofibrosis
  • hereditary spherocytosis
  • rare lymphoma
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