Myelodysplastic syndromes Flashcards

1
Q

pathology of aplastic anemia

A

immunological attack against hematopoietic stem cells

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2
Q

pathology of paroxysmal hemoglobinuria

A

mutation in PK gene allowing them to escape the immune system but still be killed by the complement system

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3
Q

age related clonal hematopoiesis ARCH

A

increases risk of CV disease bc TET2 mutated cell induce inflammation which is a risk factor for atherosclerosis

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4
Q

most important MDS is

A

5q- syndrome. This has hyperactivation of p53. Treat with lenalidomide

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