Multiple Myeloma Flashcards
1
Q
where do we find plasma cells
A
in connective tissue
2
Q
what is common with Multiple myeloma
A
end organ damage, in bones and kidneys (amyloidosis)
3
Q
MGUS stands for
A
monoclonal gammopathy of undetermined significance
4
Q
how to diagnose MGUS
A
- presence of serum monoclonal protiens
- monoclonal component>3g
- absence of end organ damage
5
Q
risk of MM development depends on
A
- Size of monoclonal component (if <1.5g low risk, >1.5g high risk)
- Protein type IgA/IgM vs IgG
- Serum free light chain ratio (>1.65 or <0.26)
6
Q
diagnostic tests for MM are (CRABS)
A
- calcemia
- creatinine clearance
- creatinine concentration
- CBC
- bone lesion test
- bone marrow aspiration
- free light chain detection
7
Q
treatment of MM
A
- VRD (bortezomib, lenalidomide, dexamethasone)
- ASCT
